Dr. Ksenija Zahradka
Ruđer Bošković Institute
Bijenička 54
10000 Zagreb
Croatia
Education
1991 B.Sc. in Molecular Biology, Faculty of Science, University of Zagreb, Croatia
1994 M.Sc. in Biology, Faculty of Science, University of Zagreb, Croatia
1999 Ph.D. in Biology, Faculty of Science, University of Zagreb, Croatia
2002 Postdoctoral training in the group of Prof. Miroslav Radman, Faculté de Médecine Necker, Université Paris-Descartes, Paris, France
Projects
2023- "Alternative pathways of DNA recombination and repair in Escherichia coli and Deinococcus radiodurans" (IP-2022-10-7476), Croatian Science Foundation; Principal Investigator
2017-2022 "Bioprospecting of Adriatic Sea" (KK.01.1.1.01), European Regional Development Fund, WP1: "Research on biodiversity and genetic resources of marine habitats"; Associate
2014-2018 "DNA recombination, repair and maintenance of genome integrity: new pathways" (IP-2013-11-2978), Croatian Science Foundation ; Associate
2011-2015 "Biology of Robustness", Mediterranean Institute for Life Sciences (MedILS), Split, Croatia; Associate
2007-2013 "Molecular mechanisms of DNA recombination and repair" (098-0982913-2862), Croatian Ministry of Science, Education and Sports ; Associate
2007-2010 "Life under extreme conditions", Mediterranean Institute for Life Sciences (MedILS), Split, Croatia; Co-leader
2002-2006 "Regulation of recombination and recombinational repair" (00981002), Croatian Ministry of Science, Education and Sports ; Associate
1997-2001 "Regulation of recombination and recombinational DNA repair" (00981002), Croatian Ministry of Science and Technology; Associate
1994-1997 "Genes and enzymes involved in inhibition of recombination" (CRP/CRO93-01), UNIDO/ICGEB; Associate
Awards and Achievements
2007 National Annual Science Award, Croatian Parliament
2006 Excellence in Science Grant, Croatian Ministry of Science and Education
2002 Necker Institute Postdoctoral Fellowship, Paris, France
Classes
Course “Genetic recombination and DNA repair”, PhD studies in Biology, Faculty of Science, University of Zagreb
Course “Mechanisms of DNA damage and repair”, PhD studies in Molecular Biosciences, University of Osijek, University of Dubrovnik and Ruđer Bošković Institute, Zagreb
Featured Publications
Zahradka, K., Repar, J., Đermić, D., Zahradka, D. (2023) Chromosome Segregation and Cell Division Defects in Escherichia coli Recombination Mutants Exposed to Different DNA-Damaging Treatments. Microorganisms 11:701. doi: 10.3390/microorganisms11030701
Repar, J., Zahradka, D., Sović, I., Zahradka, K. (2021) Characterization of gross genome rearrangements in Deinococcus radiodurans recA mutants. Sci Rep. 11: 10939. doi: 10.1038/s41598-021-89173-9
Buljubašić, M., Hlevnjak, A., Repar, J., Đermić, D., Filić, V., Weber, I., Zahradka, K., Zahradka, D. (2019) RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli. DNA Repair 83: 102670. doi: 10.1016/j.dnarep.2019.102670
Repar, J., Supek, F., Klanjscek, T., Warnecke, T., Zahradka, K., Zahradka, D. (2017) Elevated rate of genome rearrangements in radiation-resistant bacteria. Genetics 205: 1677-1689.
Buljubašić, M., Zahradka, D., Zahradka, K. (2013) RecQ helicase acts before RuvABC, RecG and XerC proteins during recombination in recBC sbcBC mutants of Escherichia coli. Res. Microbiol. 164: 987-997.
Buljubašić, M., Repar, J., Zahradka, K., Đermić, D., Zahradka, D. (2012) RecF recombination pathway in Escherichia coli cells lacking RecQ, UvrD and HelD helicases. DNA Repair 11: 419-430.
Repar, J., Cvjetan, S., Slade, D., Radman, M., Zahradka, D., Zahradka, K. (2010) RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans. DNA Repair 9: 1151-1161.
Zahradka, K., Buljubašić, M., Petranović, M., Zahradka, D. (2009) Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli. J. Bacteriol. 191: 1677-1687.
Zahradka, K., Slade, D., Bailone, A., Sommer, S., Averbeck, D., Petranovic, M., Lindner, A. B., Radman, M. (2006) Reassembly of shattered chromosomes in Deinococcus radiodurans. Nature 443: 569-573.
Zahradka, K., Šimić, S., Buljubašić, M., Petranović, M., Đermić, D., Zahradka, D. (2006) sbcB15 and delsbcB mutations activate two types of RecF recombination pathway in Escherichia coli. J. Bacteriol. 188: 7562-7571.
Publications - book chapters
Izvorni znanstveni rad
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Zahradka, Ksenija ; Zahradka, Davor | Reckless DNA Degradation // Brenner's Encyclopedia of Genetics (2nd ed.). | San Diego (CA): Academic Press, 2013. str. 72-74 . doi: 10.1016/B978-0-12-374984-0.01272-9
doidoi.orgwww.sciencedirect.com Zahradka, Ksenija | Izdvajanje DNA bakteriofaga // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 171-174
Zahradka, Davor ; Zahradka, Ksenija | Prijenos gena transdukcijom pomoću faga P1 // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 919-922-x
Zahradka, Ksenija | Elektroforeza DNA u promjenjivom električnom polju (PFGE) // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 206-209-x
Zahradka, Ksenija | Izdvajanje visokomolekularne genomske DNA za elektroforezu u promjenjivom električnom polju (PFGE) // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 189-191-x
Zahradka, Ksenija | Izdvajanje genomske DNA iz bakterija // Metode u molekularnoj biologiji. | Zagreb: Institut Ruđer Bošković, 2007. str. 141-143-x
Publications - journal articles
Izvorni znanstveni rad
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Pipalović, Goran; Filić, Želimira; Ćehić, Mirsada; Paradžik, Tina; Zahradka, Ksenija; Crnolatac, Ivo; Vujaklija, Dušica | Impact of C-terminal domains of paralogous single-stranded DNA binding proteins from Streptomyces coelicolor on their biophysical properties and biological functions // International journal of biological macromolecules, 268 (2024), Part 1; 131544, 11. doi: 10.1016/j.ijbiomac.2024.131544
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Zahradka, Ksenija; Zahradka, Davor; Repar, Jelena | Structural Differences between the Genomes of Deinococcus radiodurans Strains from Different Laboratories // Genes, 15 (2024), 7; 847, 14. doi: 10.3390/genes15070847
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Pipalović, Goran; Filić, Želimira; Ćehić, Mirsada; Paradžik, Tina; Zahradka, Ksenija; Crnolatac, Ivo; Vujaklija, Dušica | Impact of C-terminal domains of paralogous single-stranded DNA binding proteins from Streptomyces coelicolor on their biophysical properties and biological functions // International journal of biological macromolecules, 268 (2024), Part 1; 131544, 1. doi: 10.1016/j.ijbiomac.2024.131544
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Zahradka, Ksenija ; Repar, Jelena ; Đermić, Damir ; Zahradka, Davor | Genetic analysis of transductional recombination in Escherichia coli reveals differences in the postsynaptic stages of RecBCD and RecFOR pathways // Periodicum biologorum, 124 (2022), 3-4; 97-106. doi: 10.18054/pb.v124i3-4.23604
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Zahradka, Ksenija ; Repar, Jelena ; Đermić, Damir ; Zahradka, Davor | Chromosome Segregation and Cell Division Defects in Escherichia coli Recombination Mutants Exposed to Different DNA-Damaging Treatments // Microorganisms, 11 (2023), 3; 11030701, 30. doi: 10.3390/microorganisms11030701
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Repar, Jelena ; Zahradka, Davor ; Sović, Ivan ; Zahradka, Ksenija | Characterization of gross genome rearrangements in Deinococcus radiodurans recA mutants // Scientific reports, 11 (2021), 1; 10939, 11. doi: 10.1038/s41598-021-89173-9
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Buljubašić, Maja ; Hlevnjak, Ana ; Repar, Jelena ; Đermić, Damir ; Filić, Vedrana ; Weber, Igor ; Zahradka, Ksenija ; Zahradka, Davor | RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli // DNA repair, 83 (2019), 102670, 16. doi: 10.1016/j.dnarep.2019.102670
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Feliciello, Isidoro ; Zahradka, Davor ; Zahradka, Ksenija ; Ivanković, Siniša ; Puc, Nikolina ; Đermić, Damir | RecF, UvrD, RecX and RecN proteins suppress DNA degradation at DNA double-strand breaks in Escherichia coli // Biochimie, 148 (2018), 116-126. doi: 10.1016/j.biochi.2018.03.005
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Repar, Jelena ; Supek, Fran ; Klanjšček, Tin ; Warnecke, Tobias ; Zahradka, Ksenija ; Zahradka, Davor | Elevated rate of genome rearrangements in radiation-resistant bacteria // Genetics, 205 (2017), 4; 1677-1689. doi: 10.1534/genetics.116.196154
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Repar, Jelena ; Šućurović, Sandra ; Zahradka, Ksenija ; Zahradka, Davor ; Ćurković-Perica, Mirna | Stress resistance of Escherichia coli and Bacillus subtilis is modulated by auxins // Canadian journal of microbiology, 59 (2013), 11; 766-770. doi: 10.1139/cjm-2013-0266
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Buljubašić, Maja ; Zahradka, Davor ; Zahradka, Ksenija | RecQ helicase acts before RuvABC, RecG and XerC proteins during recombination in recBCD sbcBC mutants of Escherichia coli // Research in microbiology, 164 (2013), 10; 987-997. doi: 10.1016/j.resmic.2013.08.008
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Repar, Jelena ; Zahradka, Davor ; Zahradka, Ksenija | Accuracy of genome reassembly in gamma-irradiated Escherichia coli // Food technology and biotechnology, 51 (2013), 3; 327-337
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Repar, Jelena ; Briški, Nina ; Buljubašić, Maja ; Zahradka, Ksenija ; Zahradka, Davor | Exonuclease VII is involved in "reckless" DNA degradation in UV-irradiated Escherichia coli // Mutation research. Genetic toxicology and environmental mutagenesis, 750 (2013), 1/2; 96-104. doi: 10.1016/j.mrgentox.2012.10.005
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Buljubašić, Maja ; Repar, Jelena ; Zahradka, Ksenija ; Đermić, Damir ; Zahradka, Davor | RecF recombination pathway in Escherichia coli cells lacking RecQ, UvrD and HelD helicases // DNA repair, 11 (2012), 4; 419-430. doi: 10.1016/j.dnarep.2012.01.011
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Repar, Jelena ; Cvjetan, Svjetlana ; Slade, Dea ; Radman, Miroslav ; Zahradka, Davor ; Zahradka, Ksenija | RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans // DNA repair, 9 (2010), 11; 1151-1161. doi: 10.1016/j.dnarep.2010.08.003
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Zahradka, Ksenija ; Buljubašić, Maja ; Petranović, Mirjana ; Zahradka, Davor | Roles of ExoI and SbcCD nucleases in "reckless" DNA degradation in recA mutants of Escherichia coli // Journal of bacteriology, 191 (2009), 5; 1677-1687. doi: 10.1128/JB.01877-07
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Petranović, Dina ; Michelsen, Ole ; Zahradka, Ksenija ; Silva, Catarina ; Petranović, Mirjana ; Jensen, Peter Ruhdal ; Mijaković, Ivan | Bacillus subtilis strain deficient for the protein-tyrosine kinase PtkA exhibits impaired DNA replication // Molecular microbiology, 63 (2007), 6; 1797-1805. doi: 10.1111/j.1365-2958.2007.05625.x
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Zahradka, Ksenija ; Slade, Dea ; Bailone, Adriana ; Sommer, Suzanne ; Averbeck, Dietrich ; Petranović, Mirjana ; Lindner, Ariel B. ; Radman, Miroslav | Reassembly of shattered chromosomes in Deinococcus radiodurans // Nature, 443 (2006), 569-573. doi: 10.1038/nature05160
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Zahradka, Ksenija ; Šimić, Sanela ; Buljubašić, Maja ; Petranović, Mirjana ; Đermić, Damir ; Zahradka, Davor | sbcB15 and delsbcB mutations activate two types of RecF recombination pathway in Escherichia coli // Journal of bacteriology, 188 (2006), 21; 7562-7571. doi: 10.1128/JB.00613-06
doijournals.asm.org Zahradka, Ksenija ; Zahradka, Davor ; Đermić, Damir ; Džidić, Senka ; Petranović, Mirjana | The inactivation of free phages in UV-irradiated Escherichia coli // Periodicum biologorum, 104 (2002), 4; 399-403
Zahradka, Davor ; Zahradka, Ksenija ; Džidić, Senka ; Đermić, Damir ; Petranović, Mirjana | The rus-1 mutation suppresses cytological defects in recBC sbcBC ruv mutants of Escherichia coli // Periodicum biologorum, 104 (2002), 4; 389-397-x
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Zahradka, Davor ; Zahradka, Ksenija ; Petranović, Mirjana ; Đermić, Damir ; Brčić-Kostić, Krunoslav | The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichia coli // Journal of bacteriology, 184 (2002), 15; 4141-4147. doi: 10.1128/JB.184.15.4141-4147.2002
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Petranović, Mirjana ; Zahradka, Ksenija ; Zahradka, Davor ; Petranović, Dina ; Nagy, Biserka ; Salaj-Šmic, Erika ; Petranović, Dragutin | Genetic evidence that the elevated levels of Escherichia coli helicase II antagonize recombinational DNA repair // Biochimie, 83 (2001), 11-12; 1041-1047. doi: 10.1016/S0300-9084(01)01346-3
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Paškvan, Ivan ; Salaj-Šmic, Erika ; Ivančić-Baće, Ivana ; Zahradka, Ksenija ; Trgovčević, Željko ; Brčić-Kostić, Krunoslav | The genetic dependence of RecBCD-Gam mediated double strand end repair in Escherichia coli // FEMS microbiology letters, 205 (2001), 2; 299-303. doi: 10.1111/j.1574-6968.2001.tb10964.x
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Zahradka, Ksenija ; Zahradka, Davor ; Petranović, Mirjana | Loss of lambda prophage recombinogenicity in UV- irradiated Escherichia coli : the role of host genes ruvA, ruvB, ruvC and recG // Research in microbiology, 152 (2001), 10; 873-881. doi: 10.1016/S0923-2508(01)01270-0
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Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Drago | Progressive loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli : the role of RecBCD enzyme // Research in microbiology, 151 (2000), 9; 727-738. doi: 10.1016/S0923-2508(00)01138-4
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Petranović, Mirjana ; Vlahović, Ksenija ; Zahradka, Davor ; Džidić, Senka ; Radman, Miroslav | Mismatch repair in Xenopus egg extracts is not strand-directed by DNA methylation // Neoplasma, 47 (2000), 6; 375-381
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Zahradka, Davor ; Vlahović, Ksenija ; Petranović, Mirjana ; Petranović, Drago | Chromosome segregation and cell division defects in recBC sbcBC ruvC mutants of Escherichia coli // Journal of bacteriology, 181 (1999), 19; 6179-6183. doi: 10.1128/JB.181.19.6179-6183.1999
doijournals.asm.org Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Dragutin | Effects of ruv and recG mutations on lambda prophage thermoinducibility in UV-irradiated Escherichia coli // Periodicum biologorum, 100 (1998), 3; 383-388-x
Popularni rad
Zahradka, Ksenija | Miroslav Radman - život i djelo // Priroda (Zagreb), 101 (2011), 7/8; 46-49
Publications - conference proceedings
Sažetak izlaganja sa skupa
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Zahradka, Ksenija ; Repar, Jelena ; Đermić, Damir ; Zahradka, Davor | Chromosome segregation and cell division defects in Escherichia coli after induction of double- strand DNA breaks // Power of Microbes in Industry and Environment 2023: Book of Abstracts / Teparić, Renata; Leboš Pavunc, Andreja; Kifer, Domagoj (ur.). | Zagreb: Croatian Microbiological Society, 2023. str. 73-73
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Buljubašić, Maja ; Zahradka, Ksenija ; Hlevnjak, Ana ; Repar, Jelena ; Đermić, Damir ; Zahradka, Davor | RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli // 4th Congress of Croatian Geneticists with international participation - Book of Abstracts. | Zagreb: Hrvatsko genetičko društvo, 2018. str. 25-25
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Repar, Jelena ; Supek, Fran ; Klanjscek, Tin ; Warnecke, Tobias ; Zahradka, Ksenija ; Zahradka, Davor | Genome rearrangements in radiation-resistant bacteria // 4th Congress of Croatian Geneticists with international participation : Book of Abstracts. | Zagreb: Hrvatsko genetičko društvo, 2018. str. 24-24
pubweb.carnet.hr Zahradka, Ksenija ; Hlevnjak, Ana ; Repar, Jelena ; Buljubašić, Maja ; Zahradka, Davor | Genetic differences in postsynaptic stages of two recombinational repair pathways in Escherichia coli // EEMGS 2016 Annual Meeting - Programme & Abstract book. | Kopenhagen, 2016. str. 146-146
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Zahradka, Ksenija ; Repar, Jelena ; Buljubašić, Maja ; Zahradka, Davor | ExoI, ExoVII and SbcCD nucleases participate in "reckless" DNA degradation in Escherichia coli // BioMicroWorld 2013 - Book of Abstracts. | 2013. str. 534-534
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Repar, Jelena ; Supek, Fran ; Zahradka, Davor ; Zahradka, Ksenija | Elevated rate of gene order change in radiation-resistant Deinococci // FEMS 2013 - 5th Congress of European Microbiologists. | 2013
www2.kenes.com Buljubašić, Maja ; Repar, Jelena ; Zahradka, Ksenija ; Đermić, Damir ; Zahradka, Davor | Roles of RecQ, UvrD and HelD helicases in the RecF recombination pathway of Escherichia coli // Book of Abstracts of the 3rd Congress of Croatian Geneticists with international participation. | Zagreb: Hrvatsko genetičko društvo, 2012. str. 11-11
Repar, Jelena ; Cvjetan, Svjetlana ; Slade, Dea ; Radman, Miroslav ; Zahradka, Davor ; Zahradka, Ksenija | Fidelity of DNA repair and genome stability in Deinococcus radiodurans // Book of Abstracts of the 3rd Congress of Croatian Geneticists with international participation. | Zagreb: Hrvatsko genetičko društvo, 2012. str. 10-10
Zahradka, Ksenija ; Buljubašić, Maja ; Petranović, Mirjana ; Zahradka, Davor | ExoI and SbcCD nucleases are involved in "reckless" chromosome degradation in recA mutants of Escherichia coli / Nukleaze ExoI i SbcCD sudjeluju u neobuzdanoj razgradnji kromosoma u recA mutantima bakterije Escherichia coli // 10. hrvatski biološki kongres s međunarodnim sudjelovanjem - Zbornik sažetaka. | Zagreb: Hrvatsko biološko društvo, 2009. str. 69-70
Vučemilović, Ante ; Petranović, Mirjana ; Popović Hadžija, Marijana ; Korolija, Marina ; Zahradka, Ksenija ; Hadžija Mirko | Application of 16S ribosomal RNA sequence in the identification of laboratory strains of Bacillus species in the warfare polymer fibre // 4th Croatian Congress of Microbiology with International Participation. | Zadar, 2008
Repar, Jelena ; Cvjetan, Svjetlana ; Zahradka, Davor ; Radman, Miroslav ; Zahradka, Ksenija | Popravak DNA i stabilnost genoma u bakteriji Deinococcus radiodurans // 50 godina molekularne biologije u Hrvatskoj - Zbornik sažetaka. | Zagreb: Institut Ruđer Bošković, 2008. str. 32-32
Buljubašić, Maja ; Zahradka, Ksenija ; Petranović, Mirjana ; Zahradka, Davor | ExoI and SbcCD nucleases cooperate with RecBCD enzyme in reckless chromosome degradation in recA mutants of Escherichia coli // 50 godina molekularne biologije u Hrvatskoj - Zbornik sažetaka. | Zagreb: Institut Ruđer Bošković, 2008. str. 57-57
Zahradka, Ksenija ; Buljubašić, Maja ; Petranović, Mirjana ; Zahradka, Davor | ExoI and SbcCD nucleases cooperate with RecBCD enzyme in reckless chromosome degradation in recA mutants of Escherichia coli // 4th Croatian Congress of Microbiology with International Participation - Programme and Abstracts. | Zagreb: Hrvatsko mikrobiološko društvo, 2008. str. 22-22
Zahradka, Ksenija ; Slade, Dea ; Bailone, Adriana ; Sommer, Suzanne ; Averbeck, Dietrich ; Petranović, Mirjana ; Lindner, Ariel ; Radman, Miroslav | DNA repair in radiation resistant bacterium Deinococcus radiodurans // HDBMB2008 Congress of the Croatian Society of Biochemistry and Molecular Biology With International Participation - Book of Abstracts. | Osijek: Hrvatsko Društvo za Biotehnologiju, 2008. str. 44-44
Zahradka, Ksenija | Survival of Deinococcus radiodurans in extreme environments // MedILS Summer School 2008 "Life in Extreme Conditions". | 2008
Zahradka, Ksenija ; Slade, Dea ; Bailone, Adriana ; Sommer, Suzanne ; Averbeck, Dietrich ; Petranovic, Mirjana ; Lindner, Ariel ; Radman, Miroslav | Survival of Deinococcus radiodurans in extreme conditions: genome restoration by recombination // Power of microbes in industry and environment 2007 - Central European Symposium on Industrial Microbiology and Microbial Ecology. | Zagreb: Hrvatsko mikrobiološko društvo, 2007. str. 23-23-x
Zahradka, Ksenija | DNA repair in Deinococcus radiodurans: surviving extreme life conditions // MedILS Summer School 2007 "Survivng death - an interdisciplinary approach workshop". | 2007
Zahradka, Ksenija ; Slade, Dea ; Bailone, Adriana ; Sommer, Suzanne ; Averbeck, Dietrich ; Petranović, Mirjana ; Lindner, Ariel ; Radman, Miroslav | DNA repair in Deinococcus radiodurans: from hundreds of fragments to the functional chromosomes // Current Trends in Biomedicine Workshop: Mechanism and biological consequences of recombinational DNA repair-mediated genome instability. | Baeza, 2006
Buljubašić, Maja ; Zahradka, Ksenija ; Petranović, Mirjana ; Zahradka, Davor | Effects of a recG mutation on homologous recombination and DNA repair in recBC sbcBC mutants of Escherichia coli // 1st MedILS Summer School, Structure and Evolution: from Bench to Terminal (Abstract Book). | 2006. str. 25-25-x
Zahradka, Davor ; Zahradka, Ksenija ; Buljubašić, Maja ; Petranović, Mirjana | The role of SbcB and SbcCD nucleases in spontaneous DNA degradation in recA mutants of Escherichia coli // Zbornik sažetaka 9. hrvatskog biološkog kongresa s međunarodnim sudjelovanjem. | Zagreb: Hrvatsko biološko društvo, 2006. str. 84-85-x
Buljubašić, Maja ; Zahradka, Ksenija ; Petranović, Mirjana ; Zahradka, Davor | Effects of a recG mutation on homologous recombination and DNA repair in recBC sbcBC mutants of Escherichia coli // Zbornik sažetaka 9. hrvatskog biološkog kongresa s međunarodnim sudjelovanjem. | Zagreb: Hrvatsko biološko društvo, 2006. str. 71-73-x
Zahradka, Ksenija ; Radman, Miroslav | DNA repair in Deinococcus radiodurans: from hundreds of fragments to the functional chromosome // Zbornik sažetaka 9. hrvatskog biološkog kongresa s međunarodnim sudjelovanjem. | Zagreb: Hrvatsko biološko društvo, 2006. str. 59-60-x
Zahradka, Davor ; Buljubašić, Maja ; Zahradka, Ksenija ; Petranović, Mirjana | Effects of a recG Mutation on Homologous Recombination and Recombinational DNA Repair in recBC sbcBC Mutants of Escherichia coli // Book of Abstracts. Second Congress of Croatian Geneticists with International Participation. | Zagreb: Hrvatsko genetičko društvo, 2005. str. 84-84-x
Zahradka, Ksenija ; Bailone, Adriana ; Averbeck, Dietrich ; Petranović, Mirjana ; Radman, Miroslav | Reconstitution of Deinococcus radiodurans Chromosomes Shattered by Radiation Involves DNA Replication and Recombination // Book of Abstracts. Second Congress of Croatian Geneticists. | Zagreb: Hrvatsko genetičko društvo, 2005. str. 55-55-x
Zahradka, Davor ; Zahradka, Ksenija ; Petranović, Mirjana | Cytological defects in recBC sbcBC ruv mutants of Escherichia coli // Zbornik = Proceedings / Treći hrvatski mikrobiološki kongres s međunarodnim sudjelovanjem, Poreč, 4.-7. listopada 2004.. | Zagreb: Hrvatsko mikrobiološko društvo, 2004. str. 88-88-x
Zahradka, Ksenija ; Bailone, Adriana ; Averbeck, Dietrich ; Radman, Miroslav | Reconstitution of Deinococcus radiodurans genome after gamma irradiation // Zbornik = Proceedings / Treći hrvatski mikrobiološki kongres s međunarodnim sudjelovanjem, Poreč, 4.-7. listopada 2004.. | Zagreb: Hrvatsko mikrobiološko društvo, 2004. str. 45-45-x
Zahradka, Davor ; Zahradka, Ksenija ; Petranović, Mirjana | Suppression of cytological defects in recBC sbcBC ruv mutants of Escherichia coli // EMBO Conference on Molecular Microbiology: Exploring Prokaryotic Diversity - Abstract Book. | Heidelberg: EMBL, 2004. str. 127-127-x
Zahradka, Ksenija ; Bailone, Adriana ; Averbeck, Dietrich ; Radman, Miroslav | The mechanism of DNA repair in radioresistant bacterium Deinococcus radiodurans // 2nd Scientific Symposium with International Participation "45 Years of Molecular Biology in Croatia 50 Years of Double Helix", Book of Abstracts. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003. str. 25-25-x
Zahradka, Davor ; Zahradka, Ksenija ; Đermić, Damir ; Brčić-Kostić, Krunoslav ; Petranović, Mirjana | The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichia coli // 2nd Scientific Symposium with International Participation "45 Years of Molecular Biology in Croatia 50 Years of Double Helix", Book of Abstracts. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003. str. 24-25-x
Petranović, Dina ; Džidić, Senka ; Zahradka, Davor ; Zahradka, Ksenija ; Petranović, Mirjana | Activation and inhibition of lambda phage multiplicity reactivation // 2nd Scientific Symposium with International Participation "45 Years of Molecular Biology in Croatia 50 Years of Double Helix", Book of Abstracts. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003. str. 23-23-x
Zahradka, Ksenija ; Bailone, Adriana ; Averbeck, Dietrich ; Radman, Miroslav | Mechanism of DNA repair in radioresistant bacterium Deinococcus radiodurans // Proceedings of Abstracts of the 8th Croatian Biological Congress. | Zagreb: Hrvatsko biološko društvo, 2003. str. 47-48-x
Petranović, Dina ; Zahradka, Ksenija ; Zahradka, Davor ; Džidić, Senka ; Petranović, Mirjana | Genetic analysis of multiplicity reactivation of UV-irradiated lambda phage // Proceedings of Abstracts of the 8th Croatian Biological Congress. | Zagreb: Hrvatsko biološko društvo, 2003. str. 45-46-x
Paškvan, Ivan ; Salaj-Šmic, Erika ; Ivančić-Baće, Ivana ; Zahradka, Ksenija ; Lerš, Nella ; Brčić-Kostić, Krunoslav | The genetic depedence of RecBCD-Gam mediated double strand end repair in Escherichia coli // 1st Croatian Congress on Molecular Life Sciences with international participation, Book of Abstracts. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2002. str. 95-x
Petranović, Mirjana ; Vlahović, Ksenija ; Zahradka, Davor ; Salaj-Šmic, Erika ; Petranović, Drago | Genetics of antirecombination in SOS-induced Escherichia coli // Quatrieme Colloque des 3R (Replication, recombinaison, reparation). | Pariz: INRA, 2001. str. 53-53-x
Vlahović, Ksenija ; Zahradka, Davor ; Petranović, Mirjana | RecBCD enzyme in UV-irradiated Escherichia coli interferes with site-specific and general recombination of lambda prophage // Kongres hrvatskih biokemičara i molekularnih biologa HB2000 - Knjiga sažetaka. | Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2000. str. 69-69-x
Vlahović, Ksenija ; Zahradka, Davor ; Petranović, Mirjana ; Petranović, Drago | Effects of UV radiation on genetic recombination // Zbornik radova Trećeg simpozija Hrvatskoga društva za zaštitu od zračenja / Proceedings of the Third Symposium of the Croatian Radiation Protection Association. | Zagreb: Hrvatsko društvo za zaštitu od zračenja, 1996. str. 161-161
Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Dragutin | Enzim RecBC(D) inhibira rekombinaciju profaga lambda u ozračenim stanicama Escherichia coli = RecBC(D) enzyme inhibits recombination of lambda prophage in irradiated Escherichia coli cells // Zbornik sažetaka priopćenja Šestog kongresa biologa Hrvatske = Proceedings of abstracts of the papers of the Sixth Congress of Croatian Biologists. | Zagreb: Hrvatsko biološko društvo, 1997. str. 74-75-x
Zahradka, Davor ; Vlahović, Ksenija ; Petranović, Mirjana ; Ljubešić, Nikola ; Petranović, Dragutin | Inhibicija diobe stanica Escherichia coli izazvana UV zračenjem = UV-induced division inhibition in Escherichia coli // Zbornik sažetaka priopćenja Šestog kongresa biologa Hrvatske = Proceedings of abstracts of the papers of the Sixth Congress of Croatian Biologists. | Zagreb: Hrvatsko biološko društvo, 1997. str. 75-76-x
Petranović, Dragutin ; Vlahović, Ksenija ; Zahradka, Davor ; Džidić, Senka ; Petranović, Mirjana | Antirekombinaze u stanicama Escherichia coli = Antirecombinases in Escherichia coli cells // Zbornik sažetaka priopćenja Šestog kongresa biologa Hrvatske = Proceedings of abstracts of the papers of the Sixth Congress of Croatian Biologists. | Zagreb: Hrvatsko biološko društvo, 1997. str. 68-x
Petranović, Dragutin ; Petranović, Mirjana ; Vlahović, Ksenija ; Zahradka, Davor | Genetics of anti-recombination in SOS-induced Escherichia coli // ICGEB 10 th Anniversary Symposium: Molecular Biology and Biotechnology for Development. | ICGEB, 1997. str. 31-32-x
Izvorni znanstveni rad
Zahradka, Ksenija | Deinococcus radiodurans : bakterija otporna na zračenje // Zbornik radova Sedmog simpozija Hrvatskog društva za zaštitu od zračenja. | Zagreb: Hrvatsko društvo za zaštitu od zračenja, 2008. str. 3-8
Publications - Conference journals
Sažetak izlaganja sa skupa
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Repar, Jelena; Zahradka, Davor; Zahradka, Ksenija | DNA double-strand break repair and genome stability in the bacterium Deinococcus radiodurans // Arhiv za higijenu rada i toksikologiju, 75, Suppl. 1, 2024. str. 27-27
hrcak.srce.hr -
Repar, Jelena; Zahradka, Davor; Zahradka, Ksenija | New evidence for an alternative end-joining mechanism of DNA double-strand break repair in Deinococcus radiodurans // Arhiv za higijenu rada i toksikologiju, 75, Suppl. 1, 2024. str. 194-194
hrcak.srce.hr Zahradka, Ksenija ; Bailone, Adriana ; Averbeck, Dietrich ; Petranović, Mirjana ; Radman, Miroslav | Deinococcus radiodurans: The Most Efficient DNA Repair Involves Coupled Replication and Recombination Processes // Acta microbiologica et immunologica Hungarica, 2005. str. 175-175
Zahradka, Davor ; Buljubašić, Maja ; Zahradka, Ksenija ; Petranović, Mirjana | Homologous Recombination and DNA Repair in recBC sbcBC Mutants of Escherichia coli: Effects of a recG Mutation // Acta microbiologica et immunologica Hungarica, 2005. str. 174-175
Zahradka, Davor ; Vlahović, Ksenija ; Petranović, Mirjana ; Petranović, Drago | Chromosome segregation and cell morphology in recBC sbcBC ruvC mutants of Escherichia coli // Biochimie, 1999. str. s280-x
Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Drago | RecBC(D) enzyme in UV-irradiated E. coli interferes with lambda prophage recombinogenicity // Biochimie, 1999. str. s280-x
Petranović, Mirjana ; Zahradka, Davor ; Vlahović, Ksenija ; Petranović, Dragutin | Genetic analysis of the multiplicity reactivation of UV-inactivated lambda red phage // Periodicum biologorum. Supplement, 1998. str. 39-39
Vlahović, Ksenija ; Petranović, Mirjana ; Zahradka, Davor ; Petranović, Dragutin | Recombination and antirecombination in UV-irradiated Escherichia coli: the role of ruvB, ruvC, and recG genes // Periodicum biologorum. Supplement, 1998. str. 39-39
Petranović, Mirjana ; Vlahović, Ksenija ; Zahradka, Davor ; Petranović, Dragutin | RecBC(D) enzyme in UV-irradiated E. coli interferes with site-specific and general recombination of lambda prophage // FASEB journal, 1997. str. A1194-x
Publications - Conference unpublished
Neobjavljeni prilog sa skupa
Pipalović, Goran ; Filić, Želimira ; Ćehić, Mirsada ; Paradžik, Tina ; Crnolatac, Ivo ; Zahradka, Ksenija ; Vujaklija, Dušica | Possible role of SSB protein in the regulation of antibiotic production // Summer school in applied molecular microbiology on microbial specialised metabolites | Dubrovnik, Hrvatska, 10.09.2022-17.09.2022
Repar, Jelena ; Supek, Fran ; Zahradka, Davor ; Zahradka, Ksenija | Environmentally induced increase of rearrangement rates in radiation resistant prokaryotes // SMBE 2015 - annual meeting of the Society for Molecular Biology and Evolution | Beč, Austrija, 12.07.2015-16.07.2015
Zahradka, Ksenija ; Buljubašić, Maja ; Petranović, Mirjana ; Zahradka, Davor | The role of ExoI and SbcCD nucleases in spontaneous DNA degradation in Escherichia coli recA mutants // Second John Innes-Rudjer Bošković summer school in Applied Molecular Microbiology "Microbial Secondary Metabolites: Genomes, Signals and Communities" | Dubrovnik, Hrvatska, 24.08.2008-01.09.2008
Publications - Graded papers
Doktorska disertacija
Cvjetan, Svjetlana | Kromosomski rearanžmani u ozračenim mrtvim stanicama bakterije Deinococcus radiodurans: uloga insercijskih sekvenci i proteina RecA / Zahradka, Ksenija ; Radman, Miroslav (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2013
Repar, Jelena | Točnost popravka DNA u stanicama bakterije Deinococcus radiodurans nakon gama-zračenja / Zahradka, Ksenija (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2012
Vlahović, Ksenija | Genetička analiza rekombinogenosti profaga lambda u ozračenim bakterijama Escherichia coli / Petranović, Mirjana (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 1999
Diplomski rad
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Hleb, Ana | Genomski rearanžmani u bakteriji Deinococcus radiodurans: uloga proteina RecG / Hulak, Nataša ; Zahradka, Ksenija (mentor). | Zagreb, Agronomski fakultet, 2018
urn.nsk.hr Dobša, Lidija | Popravak DNA u stacionarnim stanicama bakterije Deinococcus radiodurans / Zahradka, Ksenija (mentor). | Zagreb, Farmaceutsko-biokemijski fakultet, 2010
Vukić, Marijana | Genetička nestabilnost recA mutanata bakterije Deinococcus radiodurans / Zahradka, Ksenija (mentor). | Zagreb, Farmaceutsko-biokemijski fakultet, 2010
Šimić, Sanela | Učinak mutacija sbcB15 i delsbcB na rekombinacijski popravak molekule DNA kod recBC mutanata bakterije Escherichia coli / Zahradka, Ksenija (mentor). | Zagreb, Farmaceutsko-biokemijski fakultet, 2006
Other Publications
Radovi sa studija
Dobša, Lidija ; voditelj Zahradka, Ksenija | Otpornost na zračenje stacionarnih stanica bakterije Deinococcus radiodurans // Otpornost na zračenje stacionarnih stanica bakterije Deinococcus radiodurans, Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet, 2008
Membership in professional associations / societies
European Environmental Mutagenesis and Genomics Society (EEMGS); 2015-2019 Croatian delegate
Croatian Genetic Society: 2019-2022 Secretary; since 2022 Vice-president
Croatian Microbiological Society
Croatian Society for Biochemistry and Molecular Biology
Chair of the Knowledge and Discovery Council, Adris Foundation, Croatia (since 2015)
Scientific Board member of the Mediterranean Institute for Life Sciences (MedILS), Split, Croatia
Vice-president of the Scientific Council of Biology, Ruđer Bošković Institute, Zagreb, Croatia (2016-2022)
Mentorships
Supervisor of PhD theses:
Jelena Repar: "Fidelity of DNA repair in Υ-irradiated cells of Deinococcus radiodurans", Faculty of Science, University of Zagreb, 2012.
Svjetlana Cvjetan: "Radiation-induced chromosomal rearrangements in Deinococcus radiodurans cells: the role of insertion sequences and RecA protein", Faculty of Science, University of Zagreb, 2013.
Supervisor of diploma theses:
Sanela Šimić: "Effects of sbcB15 and ΔsbcB mutations on recombinational repair in recBC mutants of Escherichia coli", Faculty of Pharmacy and Biochemistry, University of Zagreb, 2006.
Marijana Vukić: "Genetic instability in Deinococcus radiodurans recA mutants", Faculty of Pharmacy and Biochemistry, University of Zagreb, 2010.
Lidija Dobša: "DNA repair in stationary phase Deinococcus radiodurans cells", Faculty of Pharmacy and Biochemistry, University of Zagreb, 2010.
Ana Hleb: "Genome rearrangements in Deinococcus radiodurans: the role of RecG protein", Faculty of Agriculture, University of Zagreb, 2018.
Organisation of scientific meetings:
- 52nd EEMGS Meeting & 15th ICAW, Rovinj, Croatia, 2024 - Organizing & Scientific Committee member
- 4th Congress of Croatian Geneticists with international participation, Krk, Croatia, 2018 – Scientific Committee member
- 3rd Congress of Croatian Geneticists with international participation, Krk, Croatia, 2012 – Scientific Committee member
- "Power of Microbes in Industry and Environment 2010" - Central European Symposium on Industrial Microbiology and Microbial Ecology, Malinska, Croatia, 2010 - Organizing Committee member
- 10th International Summer School in Biophysics "Supramolecular Structure and Function", Rovinj, 2009 - Organizing Committee member and Editor of the Book of Abstracts
- 10th Croatian Biological Congress with international participation, Osijek, Croatia, 2009 – Scientific Committee and Organizing Committee member
- Scientific Symposium "50 Years of Molecular Biology in Croatia", Zagreb, 2008 - President of the Organizing Committee and Editor of the Book of Abstracts
- 9th Croatian Biological Congress with international participation, Rovinj, Croatia, 2006 – Scientific Committee member
- Scientific Symposium "45 Years of Molecular Biology in Croatia and 50 Years of Double Helix", Zagreb, Croatia, 2003 - Organizing Committee member
Granted patent:
PCT/EP2006/005826 (10/05/2006) "Process for chromosomal engineering using a novel DNA repair system", M. Radman and K. Zahradka inventors.