Over 10 million people worldwide suffer from Parkinson's disease (PD), a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Current treatments are primarily symptomatic and often come with significant side effects. To date, no therapy has been found that can halt or reverse the progression of PD. In this context, phlorotannins, polyphenols produced by brown macroalgae, have emerged as promising candidates for developing new-generation therapeutics. However, research on their neuroprotective effects is still in its infancy. This project investigates the neuroprotective effects of phlorotannins derived from brown macroalgae of the Adriatic Sea. Our multidisciplinary approach combines in silico, in vitro, and in vivo methodologies to elucidate the mechanism through which these compounds may protect neural tissues and potentially mitigate PD. By utilizing both larval and adult zebrafish Danio rerio we will be able to thoroughly examine PD's progression and pathology-related symptoms across different life stages. This comprehensive strategy will enable us to assess the protective effects of phlorotannins against motor deficits, as well as biochemical and molecular alterations in the PD-induced zebrafish model, providing valuable insights into potential treatments for neurodegenerative disorders. Additionally, such an approach will provide a screening platform for determining the anti-PD effect of myriad biomolecules, thus accelerating the discovery and development of algae-based therapeutics. By creating a library of phlorotannins with neuroprotective effects from the Adriatic Sea macroalgae, this project aims to foster collaborations with the pharmacological industry, potentially leading to breakthrough treatments for neurodegenerative diseases. The implications of our findings could significantly alleviate the societal and economic/healthcare burdens associated with PD by advancing understanding and treatment options.