Dr. Vedrana Filić Mileta
Division of Molecular Biology
Bijenička cesta 54
10000 Zagreb
Croatia
Education
2008 - PhD in Natural Sciences-Biology, Faculty of Science, University of Zagreb
2004 - MSc in Natural Sciences-Biology, Faculty of Science, University of Zagreb
1999 - BSc in Molecular Biology, Faculty of Science, University of Zagreb
Projects
Regulation of large-scale endocytosis by IQGAP-related proteins IqgC and IqgD (Croatian Science Foundation)
Awards and Achievements
National award for science in 2019.
RBI award for best papers published in 2019.
Featured Publications
Putar, D., A. Čizmar, X. Chao, M. Šimić, M. Šoštar, T. Ćutić, L. Mijanović, A. Smolko, H. Tu, P. Cosson, I. Weber, H. Cai, and V. Filić. 2024. IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG. Open Biol. 14:230372.
Filić, V., Mijanović, L., Putar, D., Talajić, A., Ćetković, H., and Weber, I. (2021). Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom. Cells 10, 1592.
Marinović, M., Mijanović, L., Šoštar, M., Vizovišek, M., Junemann, A., Fonović, M., Turk, B., Weber, I., Faix, J., and Filić, V. (2019). IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis. Proc. Natl. Acad. Sci. U.S.A 116, 1289–1298.
Filić, V., Marinović, M., Šoštar, M., and Weber, I. (2018). Modulation of small GTPase activity by NME proteins. Laboratory Investigation 98, 589–601.
Junemann, A., Filić, V., Winterhoff, M., Nordholz, B., Litschko, C., Schwellenbach, H., Stephan, T., Weber, I., and Faix, J. (2016). A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis. Proc. Natl. Acad. Sci. U.S.A. 113, E7464–E7473.
Sobočanec, S., Filić, V., Matovina, M., Majhen, D., Šafranko, Ž.M., Hadžija, M.P., Krsnik, Ž., Kurilj, A.G., Šarić, A., Abramić, M., et al. (2016). Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo. Redox Biol 8, 149–159.
Filić, V., Marinović, M., Faix, J., and Weber, I. (2014). The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases. Cell. Mol. Life Sci. 71, 2775–2785.
Filić, V., Marinović, M., Faix, J., and Weber, I. (2012). A dual role for Rac1 GTPases in the regulation of cell motility. J. Cell. Sci. 125, 387–398.
Publications - editorial books
Zbornik sažetaka s konferencije
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Dicty 2023 Annual International Dictyostelium Conference : Book of Abstracts / Weber, Igor; Filić, Vedrana (ur.). Zagreb: Institut Ruđer Bošković, 2023
event.fourwaves.comapi.fourwaves.com
Publications - journal articles
Izvorni znanstveni rad
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Putar, Darija; Čizmar, Anja; Chao, Xiaoting; Šimić, Marija; Šoštar, Marko; Ćutić, Tamara; Mijanović, Lucija; Smolko, Ana; Tu, Hui; Cosson, Pierre et al. | IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG // Open Biology, 14 (2024), 1; 230372, 17. doi: 10.1098/rsob.230372
doiroyalsocietypublishing.org -
Skelin, Josipa; Đukić, Anamaria; Filić, Vedrana ; Hufbauer, Martin ; Akgul, Baki ; Thomas Miranda ; Lawrence, Banks ; Tomaić, Vjekoslav | MAML1-induced HPV E6 oncoprotein stability is required for cellular proliferation and migration of cervical tumor-derived cells // Journal of medical virology, 95 (2023), 3; 5, 19. doi: https://doi.org/10.1002/jmv.28624
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Matovina, Mihaela; Tomašić Paić, Ana; Tomić, Sanja; Brkić, Hrvoje; Horvat, Lucija; Barbarić, Lea; Filić, Vedrana; Pinterić, Marija; Jurić, Snježana; Kussayeva, Akmaral | Identification of SH2 Domain-Containing Protein 3C as a Novel, Putative Interactor of Dipeptidyl Peptidase 3 // International journal of molecular sciences, 24 (2023), 18; 14178, 19. doi: 10.3390/ijms241814178
doiwww.mdpi.com -
Bodinier, Romain ; Sabra, Ayman ; Leiba, Jade ; Marchetti, Anna ; Lamrabet, Otmane ; Ayadi, Imen ; Filić, Vedrana ; Kawata, Takefumi ; Weber, Igor ; Cosson, Pierre | Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum // Frontiers in cell and developmental biology, 9 (2021), 629200, 11. doi: 10.3389/fcell.2021.629200
doiwww.frontiersin.orgfulir.irb.hr -
Podgorski, Iva I. ; Pinterić, Marija ; Marčinko, Dora ; Popović Hadžija, Marijana ; Filić, Vedrana ; Ciganek, Ivan ; Pleše, Denis ; Balog, Tihomir ; Sobočanec, Sandra | Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells // Life sciences, 254 (2020), 117812, 13. doi: 10.1016/j.lfs.2020.117812
doiwww.sciencedirect.comdoi.org -
Pinterić, Marija ; Podgorski, Iva I. ; Popović- Hadžija, Marijana ; Filić, Vedrana ; Paradžik, Mladen ; Proust, Bastien Lucien Jean ; Dekanić, Ana ; Ciganek, Ivan ; Pleše, Denis ; Marčinko, Dora et al. | Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells // Antioxidants, 9 (2020), 4; 294, 21. doi: 10.3390/antiox9040294
doiwww.mdpi.comfulir.irb.hr -
Saidu, Nathaniel Edward Bennett ; Filić, Vedrana ; Thomas, Miranda ; Sarabia-Vega, Vanessa ; Đukić, Anamaria ; Miljković, Frane ; Banks, Lawrence ; Tomaić, Vjekoslav | PDZ Domain-Containing Protein NHERF-2 Is a Novel Target of Human Papillomavirus 16 (HPV-16) and HPV-18 // Journal of virology, 94 (2019), 1; e00663-19-e00663-19. doi: 10.1128/JVI.00663-19
doijvi.asm.orgdoi.org -
Buljubašić, Maja ; Hlevnjak, Ana ; Repar, Jelena ; Đermić, Damir ; Filić, Vedrana ; Weber, Igor ; Zahradka, Ksenija ; Zahradka, Davor | RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli // DNA repair, 83 (2019), 102670, 16. doi: 10.1016/j.dnarep.2019.102670
doidoi.orgwww.sciencedirect.com -
Marinović, Maja ; Mijanović, Lucija ; Šoštar, Marko ; Vizovišek, Matej ; Junemann, Alexander ; Fonović, Marko ; Turk, Boris ; Weber, Igor ; Faix, Jan ; Filić, Vedrana | IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis // Proceedings of the National Academy of Sciences of the United States of America, 116 (2019), 4; 1289-1298. doi: 10.1073/pnas.1810268116
doidoi.orgwww.pnas.org -
Filić, Vedrana ; Marinović, Maja ; Šoštar, Marko ; Weber, Igor | Modulation of small GTPase activity by NME proteins // Laboratory investigation, 98 (2018), 5; 589-601. doi: 10.1038/s41374-018-0023-x
doiwww.nature.com -
Junemann, A. ; Filić, Vedrana ; Winterhoff, M. ; Nordholz, B. ; Litschko, C. ; Schwellenbach, H. ; Stephan, T. ; Weber, Igor ; Faix, J. | A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis // Proceedings of the National Academy of Sciences of the United States of America, 113 (2016), 47; E7464-E7473. doi: 10.1073/pnas.1611024113
doiwww.pnas.org -
Marinović, Maja ; Šoštar, Marko ; Filić, Vedrana ; Antolović, Vlatka ; Weber, Igor | Quantitative imaging of Rac1 activity in Dictyostelium cells with a fluorescently labelled GTPase-binding domain from DPAKa kinase // Histochemistry and cell biology, 146 (2016), 3; 267-279. doi: 10.1007/s00418-016-1440-9
doilink.springer.com -
Sobočanec, Sandra ; Filić, Vedrana ; Matovina, Mihaela ; Majhen, Dragomira ; Šafranko, Željka Mačak ; Popović Hadžija, Marijana ; Krsnik, Željka ; Gudan Kurilj, Andrea ; Šarić, Ana ; Abramić, Marija et al. | Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo // Redox Biology, 8 (2016), 149-159. doi: 10.1016/j.redox.2016.01.003
doi -
Filić, Vedrana ; Marinović, Maja ; Faix, Jan ; Weber, Igor | The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases // Cellular and molecular life sciences, 71 (2014), 15; 2775-2785. doi: 10.1007/s00018-014-1606-3
doilink.springer.com -
Antolović, Vlatka ; Marinović, Maja ; Filić, Vedrana ; Weber, Igor | A simple optical configuration for cell tracking by dark-field microscopy // Journal of microbiological methods, 104 (2014), 9-11. doi: 10.1016/j.mimet.2014.06.006
doiwww.sciencedirect.com -
Bursać, Slađana ; Cokarić Brdovčak, Maja ; Pfannkuchen, Martin ; Oršolić, Ines ; Golomb, Lior ; Zhu, Yan ; Katz, Chen ; Daftuar, Lylin ; Grabušić, Kristina ; Vukelić, Iva et al. | Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress // Proceedings of the National Academy of Sciences of the United States of America, 109 (2012), 50; 20467-20472. doi: 10.1073/pnas.1218535109
doiwww.pnas.org -
Annesley, Sarah J. ; Bago, Ružica ; Herak Bosnar, Maja ; Filić, Vedrana ; Marinović, Maja ; Weber, Igor ; Mehta, Anil ; Fisher, Paul R. | Dictyostelim discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis // PLoS One, 6 (2011), 10; e26024, 11. doi: 10.1371/journal.pone.0026024
doiwww.plosone.orgwww.plosone.orgfulir.irb.hr -
Filić, Vedrana ; Marinović, Maja ; Faix, Jan ; Weber, Igor | A dual role for Rac1 GTPases in the regulation of cell motility // Journal of cell science, 125 (2012), 2; 387-398. doi: 10.1242/jcs.089680
doijcs.biologists.org -
Jeličić, Branka ; Traven, Ana ; Filić, Vedrana ; Sopta, Mary | Mitochondrial dysfunction enhances Gal4 dependent transcription // FEMS microbiology letters, 253 (2005), 2; 207-213. doi: 10.1016/j.femsle.2005.09.033
doiacademic.oup.comdoi.org -
Filić, Vedrana ; Vladić, Anton ; Štefulj, Jasminka ; Čičin-Šain, Lipa ; Balija, Melita ; Sučić, Zvonimir ; Jernej, Branimir | Monoamine Oxidases A and B Gene Polymorphisms in Migraine Patients // Journal of the neurological sciences, 228 (2005), 2; 149-153. doi: 10.1016/j.jns.2004.11.045
doiwww.sciencedirect.comdoi.org
Pregledni rad (znanstveni)
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Filić, Vedrana; Weber, Igor | A young researcher’s guide to three-dimensional fluorescence microscopy of living cells // Periodicum biologorum, 125 (2023), 1-2; 133-137. doi: 10.18054/pb.v125i1-2.25140
doihrcak.srce.hrfulir.irb.hr -
Filić, Vedrana ; Mijanović, Lucija ; Putar, Darija ; Talajić, Antea ; Ćetković, Helena ; Weber, Igor | Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom // Cells, 10 (2021), 7; 1592, 39. doi: 10.3390/cells10071592
doiwww.mdpi.comdoi.orgfulir.irb.hr
Membership in professional associations / societies
Croatian Society of Biochemistry and Molecular Biology, member of Executive Committee
Croatian Microscopy Society