Skip to main content
Category
Bilateralna znanstveno-istraživačka suradnja Ministarstva znanosti, obrazovanja i športa
Total cost
6500
EUR
Start date
Jan 1st 2024
End date
Dec 31st 2025
Status
Active

Principal investigator

The ability of arginine-rich peptides to cross the lipid bilayer and enter cytoplasm, unlike their lysine-based analogues, is intensively studied in the context of cell-penetrating peptides. Although their penetration into the bilayer followed by the membrane thinning and fluidization remains rather vague from experimental point of view, the computational studies have shown that the type or charge of lipid polar groups is one of the crucial factors in their translocation. In the framework of this project, we propose to examine the impact of short cationic hydrophobic peptides adsorbed on lipid bilayer surface on lateral and transversal movement of constitutive lipids in inner and outer leaflets. By combining experimental and computational approaches, we aim at gaining an insight into the adsorption of peptides on lateral and longitudinal movement of lipids. In particular, symmetric and asymmetric lipid membranes will be examined with calorimetric, spectroscopic and microscopic techniques on the experimental side, and MD simulations and free-energy calculations on the computational side.

This site uses cookies.. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences.