Dr. Maja Majerić Elenkov
Laboratory for stereoselective catalysis and biocatalysis
Bijenička c. 54, P.O.Box 180
10002 Zagreb,Croatia
Education
Dr. Sc., University of Zagreb, Faculty of Science, Croatia.
M. Sc., University of Zagreb, Faculty of Science, Croatia.
B. Sc., University of Zagreb, Faculty of Science, Croatia.
Projects
2020 – 2023 "Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije" (CAT PHARMA), KK.01.1.1.04.0013, project partner.
2020 – 2022 „Development of solvent resistant halohydrin dehalogenase for producing bioactive compounds“ - Croatian-chinese projekt, partner: Prof. Lixia Tang, University of Electronic Science and Technology of China, project leader.
2018 – 2022 „Enzymatic Synthesis of Fluorinated Chiral Building Blocks“ (EnzyFluor), HrZZ IP-2018-01-4493, project leader.
Featured Publications
Milčić, N.; Stepanić, V.; Crnolatac, I.; Findrik Blažević, Z.; Brkljača, Z.; Majerić Elenkov, M.; Inhibitory Effect of DMSO on Halohydrin Dehalogenase: Experimental and Computational Insights into the Influence of an Organic Co-solvent on the Structural and Catalytic Properties of a Biocatalyst, Chem. Euro. J. 2022, 28, e2022019.
DOI: 10.1002/chem.202201923; 10.1002/chem.202202869 (Front Cover); 10.1002/chem.202202870 (Cover Profile).
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Mehić, E.; Hok, L.; Wang, Q.; Dokli, I.; Svetec Miklenić, M.; Findrik Blažević, Z.; Tang, L.; Vianello, R.; Majerić Elenkov, M.; Expanding the scope of enantioselective halohydrin dehalogenases – group B, Adv. Synth. Catal. 2022, 364, 2576-2588.
DOI: 10.1002/adsc.202200342; 10.1002/adsc.202200715 (Front Cover)
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Dokli I.; Milčić N.; Marin P.; Svetec Miklenić M.; Sudar, M.; Tang, L.; Findrik Blažević Z.; Majerić Elenkov M.; Halohydrin dehalogenase-catalysed synthesis of fluorinated aromatic chiral building blocks. Catal. Commun. 2021, 152, 106285.
DOI: 10.1016/j.catcom.2021.106285
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Findrik Blažević Z.; Milčić Z.; Sudar, M.; Majerić Elenkov M.; Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering, Adv. Synth. Catal. 2021, 363, 388-410.
DOI: 10.1002/adsc.202000984
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Majerić Elenkov, M.; Čičak, M.; Smolko, A.; Knežević, A.; Halohydrin dehalogenase-catalysed transformations of epifluorohydrin. Tetrahedron Lett. 2017, 59, 406-408.
DOI: 10.1016/J.TETLET.2017.12.054
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A. Mikleušević, I. Primožić, T. Hrenar, B. Salopek-Sondi, L. Tang, M. Majerić Elenkov, Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH. Tetrahedron: Asymmetry 2016, 27, 930-935.
DOI: 10.1016/J.TETASY.2016.08.003
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Mikleušević, A.; Hameršak, Z.; Salopek-Sondi, B.; Tang, L.; Janssen, D. B.; Majerić Elenkov, M.; Oxazolidinone Synthesis through Halohydrin Dehalogenase-Catalyzed Dynamic Kinetic Resolution. Adv. Synth. Catal. 2015, 357, 1709-1714.
DOI: 10.1002/ADSC.201500111
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Majerić Elenkov, M.; Primožič, I.; Hrenar, T.; Smolko, A.; Dokli, I.; Salopek-Sondi, B.; Tang, L.; Catalytic activity of halohydrin dehalogenases towards spiroepoxides. Org. Biomol. Chem. 2012, 10, 5063-5072.
DOI: 10.1039/C2OB25470K
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Majerić Elenkov, M.; Tang, L.; Hauer, B.; Janssen, D.B.; Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed resolution of epoxides, Org. Lett. 2008, 10, 2417-2420.
DOI: 10.1021/OL800698T
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Hasnaoui, G.; Majerić Elenkov, M.; Spelberg, J.H.L.; Hauer, B.; Janssen, D.B.; Halohydrin dehalogenase: a highly promiscuous enzyme and versatile biocatalyst for enantioselective epoxide ring opening, ChemBioChem. 2008, 9, 1048-1051.
DOI: 10.1002/CBIC.200700734
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Majerić Elenkov, M.; Hoeffken, W.; Tang, L.; Hauer, B.; Janssen, D.B.; Enzyme-catalysed ring opening of epoxides for the preparation of enantiopure tertiary alcohols, Adv. Synth. Catal. 2007, 349, 2279-2285.
DOI: 10.1002/ADSC.200700146
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Majerić Elenkov, M.; Tang, L.; Hauer, B.; Janssen, D.B.; Sequential kinetic resolution catalyzed by halohydrin dehalogenase, Org. Lett. 2006, 8, 4227-4229.
DOI: 10.1021/OL061369H
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Majerić Elenkov, M.; Hauer, B.; Janssen, D.B.; Enantioselective ring opening of epoxides with cyanide catalysed by halohydrin dehalogenases: A new approach to non-racemic β-hydroxy nitriles, Adv. Synth. Catal. 2006, 348, 579-585.
DOI: 10.1002/ADSC.200505333
Publications - editorial books
Zbornik sažetaka s konferencije
Simpozij o katalizi u farmaceutskoj industriji : knjiga sažetaka / Majerić Elenkov, Maja ; Vianello, Robert ; Kirin, Srećko (ur.). Zagreb: Institut Ruđer Bošković, 2023
Publications - Conference unpublished
Neobjavljeni prilog sa skupa
Milčić, Nevena; Marić, Ana-Katarina; Kos, Krešimir; Sudar, Martina; Majerić Elenkov, Maja; Findrik Blažević, Zvjezdana | Process developments by application of reaction engineering approach: biocatalytic synthesis of enantioenriched fluorinated hydroxynitrile // ESAB E-Congress 2023 | , 27.12.2023-29.12.2023
Milčić, Nevena ; Stepanić, Višnja ; Crnolatac, Ivo ; Findrik Blažević, Zvjezdana ; Brkljača, Zlatko ; Majerić Elenkov, Maja | DMSO-induced structural and catalytic changes in C-type halohydrin dehalogenase // 10th International Congress on Biocatalysis | Hamburg, Njemačka, 28.08.2022-01.09.2022
Ćevid, Ivana ; Milčić, Nevena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana | Halohydrin dehalogenase-catalysed synthesis of (R)- epichlorohydrin // 26th International Congress of Chemical and Process Engineering CHISA 2022 | Prag, Češka Republika, 21.08.2022-25.08.2022
Mehić, Emina; Findrik Blažević, Zvjezdana; Majerić Elenkov, Maja | Biocatalytic properties of group B halohydrin dehalogenases in nucleophilic ring-opening reactions of epoxides // GRC Biocatalysis, Making Biocatalysis More Predictive: Accelerating Biocatalytic Solutions to Synthetic Challenges | Manchester (NH), Sjedinjene Američke Države, 10.07.2022-15.07.2022
Milčić, Nevena ; Sudar, Martina ; Findrik Blažević, Zvjezdana ; Majerić Elenkov, Maja | Kinetic characterization of C-type halohydrin dehalogenase in the synthesis of enantiopure fluoroaromatic compounds // Multistep Enzyme Catalyzed Processes Congress 2021 | Aachen, Njemačka, 13.09.2021-16.09.2021
Marin, Petra ; Majerić Elenkov, Maja | Activity and stability of lyophilized halohydrin dehalogenase // 6th International Conference on Biocatalysis in Non-Conventional Media (BNCM 2021) | Virtual conference, 06.05.2021-08.05.2021
Ćevid, Ivana ; Milčić, Nevena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana | Simulation of a two-step cascade reaction to yield (R)-4-chloro-3-hydroxybutyronitrile // 15th International Symposium on Biocatalysis and Biotransformations (Biotrans 2021) | Graz, Austrija; online, 19.07.2021-22.07.2021
Milčić, Nevena ; Sudar, Martina ; Dokli, Irena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana | Mathematical modelling and optimization of (R)-2- azido-1-(4-trifluoromethyl-phenyl)-ethanol synthesis catalysed by halohydrin dehalogenase // EFB2021 : European Federation of the Biotechnology Virtual conference 2021 | online, 10.05.2021-14.05.2021
Ćevid, Ivana ; Milčić, Nevena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana | Kinetic model of halohydrin dehalogenase-catalysed synthesis of (R)-ECH // European Federation of the Biotechnology 2021 | online;, 10.05.2021-14.05.2021
Višnjevac, Aleksandar ; Tušek-Božić, Ljerka ; Majerić-Elenkov, Maja ; Šepac, Dragan ; Šunjić, Vitomir ; Kojić-Prodić, Biserka | Chemical behaviour of some new 1, 4-benzodiazepin-2-ones upon Cu(II)-coordination // School on Symmetry of Crystals | Kraków, Poljska, 21.08.2001-25.08.2001
Publications - Graded papers
Magistarski rad (mr. sc. i mr. art.)
Majerić, Maja | Studij enantioselektivne redukcije para- supstituiranih 2-metil-cinamaldehida pekarskim kvascem / Šunjić, Vitomir (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 1997
Doktorska disertacija
Milčić, Nevena | Mathematical modelling and optimization of biocatalytic synthesis of fluorinated chiral building blocks / Findrik Blažević, Zvjezdana ; Majerić Elenkov, Maja (mentor). | Zagreb, Fakultet kemijskog inženjerstva i tehnologije, 2023
Mehić, Emina | Biokatalitička svojstva halogenhidrin-dehalogenaza skupine B u reakcijama nukleofilnog otvaranja epoksida / Majerić Elenkov, Maja ; FIndrik Blažević, Zvjezdana (mentor). | Zagreb, Fakultet kemijskog inženjerstva i tehnologije, 2023
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Mikleušević, Ana | Enantioselective synthesis of optically active 2-oxazolidinones and alcohols catalysed by halohydrin dehalogenases / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2016
repozitorij.pmf.unizg.hr Majerić-Elenkov, Maja | Biokatalitički generirani kiralni ligandi za homogene katalizatore na osnovi 1, 4-benzodiazepina / Šunjić Vitomir (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2003
Diplomski rad
Bolješić, Leo | Ispitivanje predaka halogenhidrin-dehalogenaza kao biokatalizatora u sintezi novih spojeva / Findrik Blažević, Zvjezdana; Majerić Elenkov, Maja (mentor). | Zagreb, Fakultet kemijskog inženjerstva i tehnologije, 2024
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Zlatić, Katarina | Razvoj metode za pripravu amida pomoću enzima i kondenzacijskog reagensa / Majerić Elenkov, Maja (mentor); Knežević, Anamarija (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2017
repozitorij.unizg.hr -
Ević, Valentina | Kinetička rezolucija fluoriranih alkohola katalizirana lipazama / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2019
urn.nsk.hr Šmidlehner, Tamara | Regioselective azidolysis of aromatic epoxides catalized by halohydrin dehalogenase / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2013
Klen, Sandra | Biokatalitička svojstva halogenhidrin dehalogenaze HheA u reakcijama nukleofilnog otvaranja epoksida / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2012
Djetelić, Mateja | Enzimska kinetička rezolucija metil-3, 4- epoksibutanoata katalizirana halogenhidrin dehalogenazama / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2009