Skip to main content

Investigating sex-specific metabolic effects of Sirtuin 3 in obesity-related diseases - Obese Sirt

Principal investigator

Project type
Znanstveno-istraživački projekti
Programme
Research Projects
Financier
Croatian Science Foundation
Start date
Dec 15th 2023
End date
Dec 14th 2027
Status
Active
Total cost
197683 EUR

This project aims to explore how Sirtuin 3 (Sirt3) and sex hormones collaborate to mitigate metabolic stress induced by a Western diet, focusing on the adipose tissue-liver crosstalk in the context of obesity-related diseases. Understanding these interactions is crucial given the global prevalence of obesity and its associated health challenges. The research utilizes advanced genetic, molecular, and imaging technologies, along with metabolomic analyses, incorporating preclinical cell cultures, mouse models, and clinical studies to decipher Sirt3's role in sex-specific susceptibility to metabolic complications linked to obesity.

This site uses cookies.. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences.