In recent years, there has been a growing interest in adopting water-based systems in organic synthesis as a more environmentally friendly alternative to organic solvents. However, despite advances in the fields of micellar systems and artificial enzymes, there are still many challenges, such as limitations in catalytic activity, reaction scope, and solubility of organic molecules. Resolving these issues is crucial to fully realize the potential of this approach.

Inspired by biological systems, STARTNOW introduces a novel pH-responsive system for organocatalysis in water featuring a modular design, allowing for a broad range of reactions and reaction selectivity. Tubular architecture will be constructed utilizing a supramolecular approach, incorporating pH-responsiveness and interchangeable catalytic functionality within a hydrophobic cavity. Accordingly, the project objectives include: i) synthesis of two types of amphiphilic water-soluble molecules, with pH-responsive and organocatalytic functionalities, ii) study of their co-assembly into tubular structures in water, iii) utilizing these supramolecular tubes for catalysis of specific organic reactions based on the embedded catalyst.

The project aims to advance micellar solutions for organic reactions to enzyme-inspired systems by combining enzymes’ superior catalytic performance with a simple design and responsiveness. Target groups covered by the project's activities include researchers in organic synthesis, green chemistry, and supramolecular materials.