dr. sc. Maja Majerić Elenkov
Institut Ruđer Bošković
Bijenička 54
HR-10000 Zagreb
Projekti
2020 – 2023 "Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije" (CAT PHARMA) Ministarstva znanosti i obrazovanja u sklopu operativnog programa "Konkurentnost i kohenzija 2014-2020", "Ulaganje u znanost i inovacije – prvi poziv", KK.01.1.1.04.0013, Voditelj projekta: Srećko Kirin, IRB, voditeljica radnog paketa.
2020 – 2022 „Development of solvent resistant halohydrin dehalogenase for producing bioactive compounds“ - hrvatsko-kineski bilateralni projekt, partner: Prof. Lixia Tang, University of Electronic Science and Technology of China, voditeljica projekta.
2018 – 2022 „Enzymatic Synthesis of Fluorinated Chiral Building Blocks“ (EnzyFluor) Hrvatska zaklada za znanost, HrZZ IP-2018-01-4493, voditeljica projekta.
2011 – 2013 “Protein engineering of halohydrin dehalogenases for the production of fine chemicals and pharmaceutical intermediates” - hrvatsko-kineski bilateralni projekt, voditeljica projekta.
2009 – 2011 ”Biocatalytic application of halohydrin dehalogenases for production of chiral building blocks”, UKF projekt “Moje prvo istraživanje”, voditeljica projekta.
Nagrade i priznanja
Priznanje timu projekta EnzyFluor (HrZZ IP-2018-01-4493) za najzahtjevnije računanje uporabom klastera Isabella u 2021. godini.
Istaknute publikacije
Milčić, N.; Stepanić, V.; Crnolatac, I.; Findrik Blažević, Z.; Brkljača, Z.; Majerić Elenkov, M.; Inhibitory Effect of DMSO on Halohydrin Dehalogenase: Experimental and Computational Insights into the Influence of an Organic Co-solvent on the Structural and Catalytic Properties of a Biocatalyst, Chem. Euro. J. 2022, 28, e2022019.
DOI: 10.1002/chem.202201923; 10.1002/chem.202202869 (Front Cover); 10.1002/chem.202202870 (Cover Profile).
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Mehić, E.; Hok, L.; Wang, Q.; Dokli, I.; Svetec Miklenić, M.; Findrik Blažević, Z.; Tang, L.; Vianello, R.; Majerić Elenkov, M.; Expanding the scope of enantioselective halohydrin dehalogenases – group B, Adv. Synth. Catal. 2022, 364, 2576-2588.
DOI: 10.1002/adsc.202200342; 10.1002/adsc.202200715 (Front Cover)
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Dokli I.; Milčić N.; Marin P.; Svetec Miklenić M.; Sudar, M.; Tang, L.; Findrik Blažević Z.; Majerić Elenkov M.; Halohydrin dehalogenase-catalysed synthesis of fluorinated aromatic chiral building blocks. Catal. Commun. 2021, 152, 106285.
DOI: 10.1016/j.catcom.2021.106285
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Findrik Blažević Z.; Milčić Z.; Sudar, M.; Majerić Elenkov M.; Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering, Adv. Synth. Catal. 2021, 363, 388-410.
DOI: 10.1002/adsc.202000984
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Majerić Elenkov, M.; Čičak, M.; Smolko, A.; Knežević, A.; Halohydrin dehalogenase-catalysed transformations of epifluorohydrin. Tetrahedron Lett. 2017, 59, 406-408.
DOI: 10.1016/J.TETLET.2017.12.054
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A. Mikleušević, I. Primožić, T. Hrenar, B. Salopek-Sondi, L. Tang, M. Majerić Elenkov, Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH. Tetrahedron: Asymmetry 2016, 27, 930-935.
DOI: 10.1016/J.TETASY.2016.08.003
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Mikleušević, A.; Hameršak, Z.; Salopek-Sondi, B.; Tang, L.; Janssen, D. B.; Majerić Elenkov, M.; Oxazolidinone Synthesis through Halohydrin Dehalogenase-Catalyzed Dynamic Kinetic Resolution. Adv. Synth. Catal. 2015, 357, 1709-1714.
DOI: 10.1002/ADSC.201500111
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Majerić Elenkov, M.; Primožič, I.; Hrenar, T.; Smolko, A.; Dokli, I.; Salopek-Sondi, B.; Tang, L.; Catalytic activity of halohydrin dehalogenases towards spiroepoxides. Org. Biomol. Chem. 2012, 10, 5063-5072.
DOI: 10.1039/C2OB25470K
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Majerić Elenkov, M.; Tang, L.; Hauer, B.; Janssen, D.B.; Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed resolution of epoxides, Org. Lett. 2008, 10, 2417-2420.
DOI: 10.1021/OL800698T
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Hasnaoui, G.; Majerić Elenkov, M.; Spelberg, J.H.L.; Hauer, B.; Janssen, D.B.; Halohydrin dehalogenase: a highly promiscuous enzyme and versatile biocatalyst for enantioselective epoxide ring opening, ChemBioChem. 2008, 9, 1048-1051.
DOI: 10.1002/CBIC.200700734
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Majerić Elenkov, M.; Hoeffken, W.; Tang, L.; Hauer, B.; Janssen, D.B.; Enzyme-catalysed ring opening of epoxides for the preparation of enantiopure tertiary alcohols, Adv. Synth. Catal. 2007, 349, 2279-2285.
DOI: 10.1002/ADSC.200700146
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Majerić Elenkov, M.; Tang, L.; Hauer, B.; Janssen, D.B.; Sequential kinetic resolution catalyzed by halohydrin dehalogenase, Org. Lett. 2006, 8, 4227-4229.
DOI: 10.1021/OL061369H
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Majerić Elenkov, M.; Hauer, B.; Janssen, D.B.; Enantioselective ring opening of epoxides with cyanide catalysed by halohydrin dehalogenases: A new approach to non-racemic β-hydroxy nitriles, Adv. Synth. Catal. 2006, 348, 579-585.
DOI: 10.1002/ADSC.200505333
Publikacije - Uredničke knjige
Zbornik sažetaka s konferencije
Simpozij o katalizi u farmaceutskoj industriji : knjiga sažetaka / Majerić Elenkov, Maja ; Vianello, Robert ; Kirin, Srećko (ur.). Zagreb: Institut Ruđer Bošković, 2023
Publikacije - prilozi sa skupa (neobjavljeni)
Neobjavljeni prilog sa skupa
Milčić, Nevena; Marić, Ana-Katarina; Kos, Krešimir; Sudar, Martina; Majerić Elenkov, Maja; Findrik Blažević, Zvjezdana | Process developments by application of reaction engineering approach: biocatalytic synthesis of enantioenriched fluorinated hydroxynitrile // ESAB E-Congress 2023 | , 27.12.2023-29.12.2023
Milčić, Nevena ; Stepanić, Višnja ; Crnolatac, Ivo ; Findrik Blažević, Zvjezdana ; Brkljača, Zlatko ; Majerić Elenkov, Maja | DMSO-induced structural and catalytic changes in C-type halohydrin dehalogenase // 10th International Congress on Biocatalysis | Hamburg, Njemačka, 28.08.2022-01.09.2022
Ćevid, Ivana ; Milčić, Nevena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana | Halohydrin dehalogenase-catalysed synthesis of (R)- epichlorohydrin // 26th International Congress of Chemical and Process Engineering CHISA 2022 | Prag, Češka Republika, 21.08.2022-25.08.2022
Mehić, Emina; Findrik Blažević, Zvjezdana; Majerić Elenkov, Maja | Biocatalytic properties of group B halohydrin dehalogenases in nucleophilic ring-opening reactions of epoxides // GRC Biocatalysis, Making Biocatalysis More Predictive: Accelerating Biocatalytic Solutions to Synthetic Challenges | Manchester (NH), Sjedinjene Američke Države, 10.07.2022-15.07.2022
Milčić, Nevena ; Sudar, Martina ; Findrik Blažević, Zvjezdana ; Majerić Elenkov, Maja | Kinetic characterization of C-type halohydrin dehalogenase in the synthesis of enantiopure fluoroaromatic compounds // Multistep Enzyme Catalyzed Processes Congress 2021 | Aachen, Njemačka, 13.09.2021-16.09.2021
Marin, Petra ; Majerić Elenkov, Maja | Activity and stability of lyophilized halohydrin dehalogenase // 6th International Conference on Biocatalysis in Non-Conventional Media (BNCM 2021) | Virtual conference, 06.05.2021-08.05.2021
Ćevid, Ivana ; Milčić, Nevena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana | Simulation of a two-step cascade reaction to yield (R)-4-chloro-3-hydroxybutyronitrile // 15th International Symposium on Biocatalysis and Biotransformations (Biotrans 2021) | Graz, Austrija; online, 19.07.2021-22.07.2021
Milčić, Nevena ; Sudar, Martina ; Dokli, Irena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana | Mathematical modelling and optimization of (R)-2- azido-1-(4-trifluoromethyl-phenyl)-ethanol synthesis catalysed by halohydrin dehalogenase // EFB2021 : European Federation of the Biotechnology Virtual conference 2021 | online, 10.05.2021-14.05.2021
Ćevid, Ivana ; Milčić, Nevena ; Majerić Elenkov, Maja ; Findrik Blažević, Zvjezdana | Kinetic model of halohydrin dehalogenase-catalysed synthesis of (R)-ECH // European Federation of the Biotechnology 2021 | online;, 10.05.2021-14.05.2021
Višnjevac, Aleksandar ; Tušek-Božić, Ljerka ; Majerić-Elenkov, Maja ; Šepac, Dragan ; Šunjić, Vitomir ; Kojić-Prodić, Biserka | Chemical behaviour of some new 1, 4-benzodiazepin-2-ones upon Cu(II)-coordination // School on Symmetry of Crystals | Kraków, Poljska, 21.08.2001-25.08.2001
Publikacije - ocjenski radovi
Magistarski rad (mr. sc. i mr. art.)
Majerić, Maja | Studij enantioselektivne redukcije para- supstituiranih 2-metil-cinamaldehida pekarskim kvascem / Šunjić, Vitomir (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 1997
Doktorska disertacija
Milčić, Nevena | Mathematical modelling and optimization of biocatalytic synthesis of fluorinated chiral building blocks / Findrik Blažević, Zvjezdana ; Majerić Elenkov, Maja (mentor). | Zagreb, Fakultet kemijskog inženjerstva i tehnologije, 2023
Mehić, Emina | Biokatalitička svojstva halogenhidrin-dehalogenaza skupine B u reakcijama nukleofilnog otvaranja epoksida / Majerić Elenkov, Maja ; FIndrik Blažević, Zvjezdana (mentor). | Zagreb, Fakultet kemijskog inženjerstva i tehnologije, 2023
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Mikleušević, Ana | Enantioselective synthesis of optically active 2-oxazolidinones and alcohols catalysed by halohydrin dehalogenases / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2016
repozitorij.pmf.unizg.hr Majerić-Elenkov, Maja | Biokatalitički generirani kiralni ligandi za homogene katalizatore na osnovi 1, 4-benzodiazepina / Šunjić Vitomir (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2003
Diplomski rad
Bolješić, Leo | Ispitivanje predaka halogenhidrin-dehalogenaza kao biokatalizatora u sintezi novih spojeva / Findrik Blažević, Zvjezdana; Majerić Elenkov, Maja (mentor). | Zagreb, Fakultet kemijskog inženjerstva i tehnologije, 2024
Zlatić, Katarina | Razvoj metode za pripravu amida pomoću enzima i kondenzacijskog reagensa / Majerić Elenkov, Maja (mentor); Knežević, Anamarija (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2017
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Ević, Valentina | Kinetička rezolucija fluoriranih alkohola katalizirana lipazama / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2019
urn.nsk.hr Šmidlehner, Tamara | Regioselective azidolysis of aromatic epoxides catalized by halohydrin dehalogenase / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2013
Klen, Sandra | Biokatalitička svojstva halogenhidrin dehalogenaze HheA u reakcijama nukleofilnog otvaranja epoksida / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2012
Djetelić, Mateja | Enzimska kinetička rezolucija metil-3, 4- epoksibutanoata katalizirana halogenhidrin dehalogenazama / Majerić Elenkov, Maja (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2009