dr. sc. Anđela Horvat
10000 Zagreb
Obrazovanje
- 2008-2015, dr. sc. biomedicine i zdravstva, poslijediplomski studij Molekularne bioznanosti na Sveučilištu u Osijeku
- 2001-2007, dipl. inž. biologije, studij molekularne biologije na Prirodoslovno-matematičkom fakultetu Sveučilišta u Zagrebu
- 1997-2001, II. gimnazija, Split
- 1989-1997, Osnovna škola "Ostrog", Kaštel Lukšić
Nagrade i priznanja
- 2018, godišnja nagrada Ravnatelja Instituta Ruđer Bošković za najbolje znanstvene radove
- 2015, EACR Meeting bursary, stipendija za sudjelovanje na konferenciji “Radiation Biology and Cancer”, Essen, Njemačka
- 2014, EACR Poster Prize, nagrada za najbolji poster na konferenciji HDIR-3 “From Bench to Clinic”, Zagreb, Hrvatska
- 2014, FEMS Young Scientist Meeting Grant, stipendija za sudjelovanje na konferenciji “Power of Viral Vectors in Gene Therapy and Basic Science” Summer School Primošten, Hrvatska
- 2008, Stipendija Vlade Republike Francuske za tromjesečno stručno usavršavanje u inozemstvu
- 1998-2007, stipendija grada Kaštela za najbolje učenike i studente
Nastava
- 2022- , izabrana u naslovno znanstveno-nastavno zvanje docenta na poslijediplomskom interdisciplinarnom sveučilišnom studiju Molekulare bioznanosti Sveučilišta Josipa Jurja Strossmayera u Osijeku
- 2011, 2012, 2015. i 2018, sudjelovanje u održavanju kolegija „Metode u molekularnoj biologiji i medicini“ i „Kontrola staničnog ciklusa, održavanje genomskog integriteta i kancerogeneza“ na poslijediplomskom studiju Molekularne bioznanosti, Sveučilišta u Osijeku kao asistent
Istaknute publikacije
- Radić M, Vlašić I, Jazvinšćak Jembrek M, Horvat A, Tadijan A, Sabol M, Dužević M, Herak Bosnar M, Slade N (2022) Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance. International Journal of Molecular Sciences 23(17):9910.
- Lossaint G*, Horvat A*, Gire V, Bačević K, Mrouj K, Charrier-Savournin F, Georget V, Fisher D, Dulić V (2022) Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest. Journal of Cell Science 135(8):jcs259114. *autori dijele prvo autorstvo
- Horvat A*, Tadijan A*, Vlašić I*, Slade N (2021) p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers 13(12):2885. *autori dijele prvo autorstvo
- Hanžić N*, Horvat A*, Bibić J, Unfried K, Jurkin T, Dražić G, Marijanović I, Slade N, Gotić M (2018) Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation. Materials Science and Engineering C: Materials for Biological Applications 91:486-495. *autori dijele prvo autorstvo
- Horvat A, Noto JM, Ramatchandirin B, Zaika E, Palrasu M, Wei J, Schneider BG, El-Rifai W, Peek Jr RM, Zaika AI (2018) Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells. Oncogene 37(37):5054-5065.
- Bhardwaj V, Gokulan RC, Horvat A, Yermalitskaya L, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI (2017) Activation of NADPH oxidases leads to DNA damage in esophageal cells. Scientific Reports 7(1):9956.
- Horvat A, Zaika AI (2017). How does bacterial pathogen Helicobacter pylori control responses to cellular stress. Future Microbiology 12: 105-108.
- Bhardwaj V, Horvat A, Korolkova O, Washington MK, El-Rifai W, Dikalov SI, Zaika AI (2016). Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts. Carcinogenesis 37(12): 1161-1169.
- Zorić A, Horvat A, Slade N (2013). Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis 34: 522-529.
- Zorić A, Horvat A, Balija M, Slade N (2012). The Arg72Pro Polymorphism of TP53 in Croatian Population. Croatica Chemica Acta 85: 239-243.
- Slade N, Horvat A (2011). Targeting p73 – A Potential Approach in Cancer Treatment. Current Pharmaceutical Design 17: 591-602.
- Zorić A, Horvat A, Slade N (2010). Obitelj gena p53 – uloga u razvoju organizma i tumorigenezi. Medicina Fluminensis 46: 135-143. (in Croatian)
- Slade N, Zorić A, Horvat A (2010). The p53/p63/p73 family of proteins – the focus on isoforms and mutants in cancer. Periodicum biologorum 112: 425-432.
Publikacije - prilozi u časopisima
Pregledni rad (znanstveni)
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Horvat, Anđela; Vlašić, Ignacija; Štefulj, Jasminka; Oršolić, Nada; Jazvinšćak Jembrek, Maja | Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies // Life, 13 (2023), 12; 2291, 33. doi: 10.3390/life13122291
doi -
Vlašić, Ignacija ; Horvat, Anđela ; Tadijan, Ana ; Slade, Neda | p53 Family in Resistance to Targeted Therapy of Melanoma // International journal of molecular sciences, 24 (2023), 1; 65, 16. doi: 10.3390/ijms24010065
doiwww.mdpi.comfulir.irb.hr -
Slade, Neda ; Zorić, Arijana ; Horvat, Anđela | The p53/p63/p73 family of proteins - the focus on isoforms and mutants in cancer // Periodicum biologorum, 112 (2010), 4; 425-432
hrcak.srce.hr -
Slade, Neda ; Horvat, Anđela | Targeting p73 - a potential approach in cancer treatment // Current pharmaceutical design, 17 (2011), 6; 591-602. doi: 10.2174/138161211795222621
doiwww.ingentaconnect.com -
Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | Obitelj gena p53 – uloga u razvoju organizma i tumorigenezi // Medicina Fluminensis, 46 (2010), 2; 135-143
hrcak.srce.hr
Izvorni znanstveni rad
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Radić, Martina ; Vlašić, Ignacija ; Jazvinšćak Jembrek, Maja ; Horvat, Anđela ; Tadijan, Ana ; Sabol, Maja ; Dužević, Marko ; Herak Bosnar, Maja ; Slade, Neda | Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance // International journal of molecular sciences, 23 (2022), 17; 9910, 19. doi: 10.3390/ijms23179910
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Lossaint Gérald, Horvat Anđela, Gire Véronique, Bačević Katarina, Mrouj Karim, Charrier-Savournin Fabienne, Georget Virginie, Fisher Dan, Dulić Vjekoslav | Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest // Journal of cell science, 135 (2022), 8; cs259114, 15. doi: 10.1242/jcs.259114
doijournals.biologists.comdoi.org -
Horvat, Anđela ; Tadijan, Ana ; Vlašić, Ignacija ; Slade, Neda | p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies // Cancers, 13 (2021), 12; 2885, 42. doi: 10.3390/cancers13122885
doiwww.mdpi.comwww.ncbi.nlm.nih.govfulir.irb.hr Horvat, Anđela ; Noto, Jennifer M ; Ramatchandirin, Balamurugan ; Zaika, Elena ; Palrasu, Manikandan ; Wei, Jinxiong ; Schneider, Barbara G ; El-Rifai, Wael ; Peek Jr, Richard M ; Zaika, Alexander I | Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells // Oncogene, 37 (2018), 37; 5054-5065
Bhardwaj, Vikas ; Gokulan, Ravindran C ; Horvat, Anđela ; Yermalitskaya, Liudmila ; Korolkova, Olga ; Washington, Kay M ; El-Rifai, Wael ; Dikalov, Sergey I ; Zaika, Alexander I | Activation of NADPH oxidases leads to DNA damage in esophageal cells // Scientific reports, 7 (2017), 1; 9956, 12
Horvat, Anđela ; Zaika, Alexander I | How does bacterial pathogen Helicobacter pylori control responses to cellular stress? // Future microbiology, 12 (2017), 105-108
Bhardwaj, Vikas ; Horvat, Anđela ; Korolkova, Olga ; Washington, Mary K ; El-Rifai, Wael ; Dikalov, Sergey I ; Zaika, Alexander I | Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts // Carcinogenesis, 37 (2016), 12; 1161-1169
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Hanžić, Nikolina ; Horvat, Anđela ; Bibić, Juraj ; Unfried, Klaus ; Jurkin, Tanja ; Dražić, Goran ; Marijanović, Inga ; Slade, Neda ; Gotić, Marijan | Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation // Materials science & engineering. C, Biomimetic materials, sensors and systems, 91 (2018), 486-495. doi: 10.1016/j.msec.2018.05.066
doiwww.sciencedirect.com -
Zorić, Arijana ; Horvat, Anđela ; Balija, Melita ; Slade, Neda | The Arg72Pro Polymorphism of TP53 in Croatian Population // Croatica chemica acta, 85 (2012), 2; 239-243. doi: 10.5562/cca1866
doihrcak.srce.hr -
Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis // Carcinogenesis, 34 (2013), 3; 522-529. doi: 10.1093/carcin/bgs370
doiwww.ncbi.nlm.nih.gov
Publikacije - prilozi sa skupa (u zborniku)
Sažetak izlaganja sa skupa
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Horvat, Anđela; Vlašić, Ignacija; Tadijan, Ana; Radić, Martina; Jazvinšćak Jembrek, Maja; Herak Bosnar, Maja; Slade, Neda | Involvement of the Δ133p53 isoform in the resistance of melanoma cell lines to targeted therapy // 19th International p53 Workshop : book of abstracts. | Trst: ICGEB International Centre For Genetic Engineering And Biotechnology, 2024. str. 100-100
www.icgeb.org -
Vlašić, Ignacija; Horvat, Anđela; Jazvinšćak Jembrek, Maja; Ozretić, Petar; Radić, Martina; Stepić, Doris; Tadijan, Ana; Slade, Neda | The role of ITIH5, a p53-regulated gene, in melanoma cell lines resistant to targeted therapy // 19th International p53 Workshop : book of abstracts. | Trst: ICGEB International Centre For Genetic Engineering And Biotechnology, 2024. str. 187-187
www.icgeb.org -
Vlašić, Ignacija ; Radić, Martina ; Jazvinšćak Jembrek, Maja ; Horvat, Anđela ; Tadijan, Ana ; Sabol, Maja ; Dužević, Marko ; Herak Bosnar, Maja ; Slade, Neda | Unique Hallmarks of Targeted Therapy Resistant Melanoma Cell Lines // “HDIR-6: Targeting Cancer” The 6th Meeting of the Croatian Association for Cancer Research with International Participation : : Book of Abstracts. | Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2022. str. 18-18
stari.hdir.hr Hanžić, Nikolina ; Horvat, Anđela ; Marijanović, Inga ; Slade, Neda ; Gotić, Marijan | Synthesis and application of gold nanoparticles to breast cancer cells // HDIR-4 - 4thMeeting with International Participation “From Bench to Clinic”. | Zagreb: Libri Oncologici, 2016. str. 35-35
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Tučkar, Neven ; Zorić, Arijana ; Horvat, Anđela ; Medvedović, Mario ; Hanžić, Nikolina ; Slade, Neda | The Effect of p73 Isoforms on DNA Methylation in Cancer Cells // Game of Epigenomics. | Zagreb: Institut Ruđer Bošković, 2016. str. 65-65
goe.irb.hr Zorić, Arijana ; Horvat, Anđela, Pfeiffer, Anamarija ; Slade, Neda | The interplay between p63/p73 and mutant p53 might be influenced by E3 ubiquitin ligase ITCH // 8th Interanational MDM2 Workshop. | New Orleans (LA), 2015
Horvat, Anđela ; Dulić, Vjekoslav ; Zorić, Arijana ; Slade, Neda | ΔNp73α compromises G2/M checkpoint inducing genomic instability in response to DNA damage // 2nd International p53 Isoforms Conference. | Aix-en-Provence, 2015. str. 42-42
Horvat, Anđela; Dulić, Vjekoslav; Zorić, Arijana; Slade, Neda | The role of ΔNp73α in DNA damage response in normal and tumor human cells // Power of viral vectors in gene therapy and basic science Book of Abstracts. | Zagreb: Recedo d.o.o, 2014. str. 55-55
Zorić, Arijana; Horvat, Anđela; Slade, Neda | Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis // 16th International p53 Workshop. | Uppsala: Karolinsta Institutet, 2014. str. 266-266
Horvat, Anđela; Dulić, Vjekoslav; Zorić, Arijana; Slade, Neda | The effect ΔNp73α on the cell cycle control after DNA damage in norma and tumor human cells // Knjiga sažetaka Kongresa Hrvatskog društva za biokemiju i molekularnu biologiju, "Međuigra biomolekula", HDBMB 2014 / Katalinić, Maja ; Kovarik, Zrinka (ur.). | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2014. str. 68-68
Zorić, Arijana ; Horvat, Anđela ; Slade, Neda. | Mutant p53 impact TAp73beta and TAp63alpha transcriptional activity and apoptosis // 6th p63/p73 International Workshop. | Chiba, 2013. str. 57-57
Zorić, Arijana ; Horvat, Anđela ; Slade, Neda. | Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis // 6th p63/p73 International Workshop. | Chiba, 2013. str. 58-58
Horvat, Anđela ; Dulić, Vjekoslav ; Zorić, Arijana ; Slade, Neda | The role of ΔNp73α in response to genotoxic stress in normal human fibroblasts // FEBS 3+ Meeting: From molecules to life and back. | Rijeka: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2012. str. 153-153
Horvat, Anđela ; Dulić, Vjekoslav ; Zorić, Arijana ; Slade, Neda | The role of ΔNp73α in response to genotoxic stress in normal human fibroblasts // 5th p63/p73 Workshop, Conference Book. | 2011
Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | The effect of p53 isoforms on p73 activity // 5th p63/p73 Workshop, Conference Book. | Lyon, 2011. str. 99-99
Zorić, Arijana ; Ružđak, Matija ; Horvat, Anđela ; Slade, Neda | Mutant p53 proteins inhibit transcriptional activity, but stabilize TAp73 due to hetereooligomer formation // 5th Mutant p53 Workshop. | Rim, 2011. str. 126-126
Slade, Neda ; Zorić, Arijana ; Horvat, Anđela ; Hofstetter, Gerda ; Berger, Astrid ; Concin, Nicole ; Zeillinger, Robert | The effect of p53 isoforms/splice variants on p73 activity // 10th Congress of the Croatian Society of Biochemistry and Molecular Biology (HDBMB 2010) : The secret of biomolecules : Abstracts. | Rijeka: Hrvatsko Društvo za Biotehnologiju, 2010. str. 69-69
Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | The effect of p53 isoforms on p73 activity in tumor cells // 1st International p53 Isoforms Meeting : p53 isoforms through evolution : from identification to biological function : abstracts. | Lyon: International Agency for Research on Cancer (IARC), 2010. str. 42-42
Zorić, Arijana ; Runje, Anđela ; Slade, Neda | p53 isoforms and p73 activity // 50 godina molekularne biologije u Hrvatskoj. | Zagreb: Institut Ruđer Bošković, 2008. str. 103-103
Ostalo
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Horvat, Anđela ; Zorić, Arijana ; Slade, Neda | p53/p63/p73 protein network // The Second Congress of the Serbian Association for Cancer Research with international participation „Cancer research: perspectives and application“ - proceedings book / Srpsko društvo istraživača raka (ur.). | Beograd: Srpsko društvo istraživača raka, 2015. str. 68-71
www.sdir.ac.rs
Publikacije - prilozi sa skupa (u časopisu)
Sažetak izlaganja sa skupa
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Hanžić, Nikolina ; Proust, Bastien Lucien Jean ; Ozretić, Petar ; Radić, Martina ; Horvat, Anđela ; Milas, Ivan ; Puljiz, Zvonimir ; Herak Bosnar, Maja ; Levanat, Sonja ; Slade, Neda | Functional interplay between p53 and p53/p73, NME and GLI protein families in human melanoma // Libri oncologici : Croatian journal of oncology, 2018. str. 51-51
hrcak.srce.hr Horvat, Anđela ; Dulić, Vjekoslav ; Zorić, Arijana ; Slade, Neda | The role of ΔNp73α in response to genotoxic stress in normal and tumor human cells // Periodicum biologorum, 114, S1, 2012. str. 31-31
Slade, Neda ; Horvat, Anđela ; Zorić, Arijana ; Poljak, Ljiljana | Smads-mediated activation of p65/NF-kappaB and Smad- 4 nuclear translocation in U4C fibrosarcoma cells // Periodicum biologorum, 114, S1, 2012. str. 68-68
Zorić, Arijana ; Horvat, Anđela ; Slade, Neda | TAp73-mediated transcriptional activity and apoptosis are influenced by diverse p53 isoforms // Periodicum biologorum, 114, S1, 2012. str. 78-78
Publikacije - ocjenski radovi
Diplomski rad
Runje, Anđela | Differences in stability of p53 tumor-suppressor protein isoforms / Slade, Neda (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2007
Doktorska disertacija
Horvat, Anđela | Utjecaj proteina ΔNp73α na kontrolu staničnog ciklusa nakon oštećenja DNA u stanicama čovjeka / Slade, Neda ; Dulić, Vjekoslav (mentor). | Osijek, Sveučilište Josipa Jurja Strossmayera u Osijeku, 2015
Članstva u profesionalnim udrugama / društvima
- Hrvatsko društvo za istraživanje raka (HDIR)
- Europsko društvo za istraživanje raka (EACR)
- Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB)
- Hrvatsko mikrobiološko društvo (HMD)
Mentorstva:
Marina Katić, Uloga proteina ΔNp73α u senescenciji izazvanoj oštećenjem DNA u normalnim i tumorskim stanicama čovjeka, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, 2021
Profesionalno usavršavanje:
- prosinac 2014, AKH (Opća bolnica u Beču), Austrija, Laboratorij za molekularnu onkologiju, pod vodstvom prof. dr. sc. Roberta Zeillingera
- rujan- prosinac 2008., Stručno usavršavanje na Institutu za molekularnu genetiku u Montpellieru (Francuska) pod vodstvom dr. sc. Vjekoslava Dulića financirano stipendijom Vlade Republike Francuske
- prosinac 2007, srpanj 2008. i lipanj 2009, Stručno usavršavanje na Institutu za molekularnu genetiku u Montpellieru (Francuska) pod vodstvom dr. sc. Vjekoslava Dulića u okviru hrvatsko-francuskog Programa integriranih akcija "Cogito"
- siječanj 2006-ožujak 2007, Izrada diplomskog rada u Laboratoriju za molekularnu onkologiju Zavoda za molekularnu medicinu Instituta Ruđer Bošković pod vodstvom dr. sc. Nede Slade na području izoformi tumor supresorskog proteina p53
- srpanj– rujan 2005, Studentska praksa na Sveučilištu u Navarri na Fakultetu prirodnih znanosti i farmacije u Pamploni, Španjolska, gdje sam laboratorijske vještine stjecala u:
- Laboratorij za fiziologiju pod vodstvom prof. dr. sc. Pilar Lostao Crespo
- Laboratorij za farmakologiju pod vodstvom dr. sc. Rosa Tordera
- Laboratorij za histologiju i anatomiju pod vodstvom prof. dr. sc. Pilar Sesma
- travanj–lipanj 2005, Proučavanje prisutstva heat shock proteina u embrijima pilića kao odgovor na temperaturni šok metodama infracrvene spektroskopije u laboratoriju Zavoda za fiziku Medicinskog fakulteta u Zagrebu pod vodstvom prof. dr. sc. Jasminke Brnjas-Kraljević
- ožujak 2004–siječanj 2005, Studentska praksa u Laboratoriju za gensku regulaciju Zavoda za molekularnu biologiju Instituta Ruđer Bošković pod vodstvom dr. sc. Mary Sopta na području molekularne genetike kvasca Saccharomyces cerevisiae