Our new paper on the role of Tyrosyl-DNA phosphodiesterase 2 (Tdp2) in DPC repair is out!
Oct 1st 2023
August, 2024
We have shown that silencing of TDP2 in zebrafish embryos causes accumulation of DNA-protein crosslinks and leads to the accumulation of double strand breaks. We found that Ku80-DPCs are removed by TDP2, whereas histone H3-DPCs are not. In addition, we have found that in vivo, TDP1 and TDP2 cannot compensate for each other, as overexpression of Tdp2 does not result in the cleavage of a Tdp1 substrate in embryos. Our results contribute to a more comprehensive understanding of DPC repair at the organismal level and underscore the significance of TDP2 in maintaining genome stability.