Dr. Oliver Vugrek
10000 Zagreb
Croatia
Education
1997-1999 Postdoctoral fellow at Australian National University (ANU), RSBS, Canberra, Australia
1996 Postdoctoral fellow at Max-Planck-Institute for Cellbiology, Heidelberg (Ladenburg), Germany
1995 PhD in biology (magna cum laude) at Ruprechts Karl University, Heidelberg, Germany
1992-1995 PhD thesis at Max-Planck-Institute for Cellbiology, Heidelberg (Ladenburg), Germany
1992 University degree in biology (Diploma) at Albert Einstein University, Ulm, Germany
1985 Abitur at grammar school 'Friedrich-Schiller-Gymnasium', Marbach, Germany
Projects
2025-2028: EASIGEN-DS Design study for a European infrastructure on advanced genomics
technologies (Proposal ID 101187908). HORIZON-INFRA-2024-DEV-01. Budget 3M EUR
(IRB 70.000,00 EUR). Project start 02/2025.
2024-2028: GOE - Genome of Europe. DIGITAL-2023-CLOUD-AI-04-GENOME (ID: 101168231).
01.10.2024 - 01.04.2028). Budget 40M EUR (IRB 610.000,00 EUR).
2024-2025: NPOO 'Dokazivanje inovativnog koncepta - Drugi Poziv', C3.2.R3-I1.05 projekt "Dokazivanje inovativnog koncepta za karakterizaciju genskih varijanti nepoznatog značaja (VUS)". Budget 66.000,00 EUR.
2022-2026: GDI - Genomic Data Infrastructure, funded from the European Union’s Digital Europe Programme under grant agreement number 101081813; 40 million EUR, Principal investigator
2019-2023: HRZZ IP IP-2018-01-5632: Molecular aspects of pathogenic processes in AHCY deficiency (Croatian Science Foundation); 985.340,48 HRK; Principal investigator
2019-2022: Centre of competence in molecular diagnostics (CEKOM); 2.204.739,05 HRK (PI: Oliver Vugrek).
2013-2016: Coordinator: FP7-REGPOT-2012-2013-1 Project - Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development (1. June 2013; EUR 4,739,000).
2012-2013 DAAD bilateral grant. Research Project AHCY deficiency: Epigenetic characterization of a novel human methylation disorder' (PI’s: Dr. Oliver Vugrek and Dr. Ulrich Zechner, Institute for Human Genetics, Mainz, Germany
2010-2012 - Project leader for grant of IPA Regional Development Component in Croatia (EUR 491,485):'Creation of research related infrastructure for Translational Medicine and Applied Genomics.
2010 – 2011: DAAD bilateral grant. Research Project ‘AHCY deficiency: Proteomics of a new methylation disorder in human' (PI’s: Dr. Oliver Vugrek and Dr. Gerhard Mittler (Max-Planck-Institute for Immunobiology, Freiburg, Germany).
2009 – 2011: CROATIA-ISRAEL JOINT RESEARCH PROGRAM: Research project ‘Molecular dynamics of S-Adenosylhomocysteine hydrolase (AHCY) and its role in regulation of gene expression (PI’s: Dr. Oliver Vugrek and Dr. Yaron Shav-Tal (Bar-Ilan University, Ramat Gan, Israel).
2007– : Croatian Ministry of Science and Technology project 098-0000000-2463; Research Project: ‘S-Adenosylhomocysteine hydrolase (AHCY) deficiency: Molecular Mechanims of a new human disease’ (PI Dr. Oliver Vugrek).
Awards and Achievements
Director's award for exceptional contribution to research at Rudjer Boskovic Institute in 2010
Classes
Postgraduate lecturer at the Medical Faculty Zagreb since 2003: Leader of courses ‘From disease to gene – from gene to function: Role of recombinant proteins in functional genomics, and Translational Medicine – From disease to gene
Postgraduate lecturer at the Natural Sciences and Mathematics Faculty Zagreb, since 2008: Leader of course 'omics' methods: Application in research of new disorders
Featured Publications
- Whittington A T, Vugrek O, Wei K, Hasenbein N G, Sugimoto K, Rashbrooke M C, Wasteneys G O: MOR1 is essential for organizing cortical microtubules in plants. Nature 2001, 411: 610-613.
- Barić I, Fumić K, Glenn B, Ćuk M, Schulze A, Finkelstein J D, Jill James S, Mejaški-Bošnjak V, Pažanin L, Pogribny I P, Radoš M, Sarnavka V, Šćukanec-Špoljar M, Allen R H, Stabler S, Uzelac L, Vugrek O, Wagner C, Zeisel S, Mudd H: S-adenosylhomocysteine hydrolase deficiency in a human: A genetic disorder of methionine metabolism. PNAS USA 2004, 101(12): 4234-4239.
- Vugrek O, Belužić R, Nakić N, Mudd SH: S-Adenosylhomocysteine hydrolase (AHCY) deficiency: Two novel mutations with lethal outcome. Human Mutation, 2009: 30 (4): E555-E565.
- Grbeša I, Kalo A, Belužić R, Kovačević L, Lepur A, Rokić F, Hochberg H, Kanter I, Simunović V, Muńoz-Torres PM, Shav-Tal Y, Vugrek O (2017). Mutations in S-adenosylhomocysteine hydrolase (AHCY) effect its nucleocytoplasmic distribution and capabilities for interaction with S-adenosylhomocysteine hydrolase-like 1 protein. European Journal of Cell Biology, 96(6):579-590. doi: 10.1016/j.ejcb.2017.05.002.
- Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020. Eurosurveillance Euro Surveill. 2020;25(32); https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001410.
- Pavičić, I., Rokić, F., Vugrek, O.*. (2023). Effects of S-Adenosylhomocysteine Hydrolase Downregulation on WNT Signaling Pathway in SW480 Cells, International Journal of Molecular Sciences. 24, no.22:16102, 2023. https://doi.org/10.3390/ijms242216102.
Publications - editorial books
Zbornik sažetaka s konferencije
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Game of Epigenomics Conference - Book of Abstracts / Vugrek, Oliver; Jerić, Ivanka; Ambriović Ristov, Andreja et al. (ur.). Zagreb: Ruđer Bošković Institute, 2016
goe.irb.hr
Publications - Conference journals
Sažetak izlaganja sa skupa
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Logara Klarić, Monika ; Trgovec-Greif, Lovro ; Žunić, Lucija ; Rokić, Filip ; Vičić, Ana ; Marić, Tihana ; Merkler, Ana ; Katušić Bojanac, Ana ; Belužić, Robert ; Stipoljev, Feodora et al. | Genetic analysis of azoospermic men by an integrated NGS panel // European journal of human genetics, 2022. str. 90-90. doi: 10.1038/s41431-021-01026-1
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Šutić, Maja; Fitzner, Antje; Bubanović, Gordana; Linke, Matthias; Lepur, Adriana; Kovačević, Lucija; Brčić, Luka; Seiwerth, Sven; Samaržija, Miroslav; Vugrek, Oliver et al. | Reduced promoter methyilation of MyD88 and ASC/TMS1 genes in tumor tissue of patients with lung carcinoma // Libri oncologici : Croatian journal of oncology, 44, 1, 2016. str. 51-51
hrcak.srce.hr Kovačević, Lucija ; Lepur, Adriana ; Grbeša, Ivana ; Belužić, Robert ; Vugrek, Oliver | „Omics“-approach to investigate cancer associated phenotypic changes in Hep G2 cells after targeted silencing of AHCY hydrolase // Libri oncologici : Croatian journal of oncology, 44, 2016. str. 40-40
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Barić, Ivo ; Ćuk, Mario ; Petković-Ramadža, Danijela ; Bilić, Karmen ; Zibar, Karin ; Sarnavka, Vladimir ; Vugrek, Oliver ; Burlina, A. ; Mudd, S.H. ; Fumić, Ksenija | S-adenosylhomocysteine hydrolase deficiency- a review of nine patients // Molecular genetics and metabolism, 2012. str. 303-303
www.sciencedirect.com -
Barić, Ivo ; Ćuk, Mario ; Petković-Ramadža, Danijela ; Bilić, Karlo ; Martinac, I. ; Sarnavka, Vladimir ; Vugrek, Oliver ; Mudd, S.H. ; Fumić, Ksenija | S-adenosylhomocysteine hydrolase deficiency : a natural model for study of various neurological problems in children with possible dysmethylation pathogenesis // European journal of paediatric neurology, 2011. str. S27-S27
www.ejpn-journal.com Ćuk, Mario ; Lovrić, Mila ; Fumić, Ksenija ; Mudd, S. Harvey ; Vugrek, Oliver ; Sarnavka, Vladimir ; Barić, Ivo | The fourth S-adenosylhomocysteine hydrolase deficient patient : Further evidence of congenital miopathy // Clinical chemistry and laboratory medicine, 2007. str. 43-43
Belužić, Robert ; Ćuk, Mario ; Pavkov, Tea ; Barić, Ivo ; Vugrek, Oliver | Functional analysis of recombinant mutant A89V S-adenosylhomocysteine hydrolase (AdoHcyase) detected ina AdoHcyase deficient patient. // Clinical chemistry and laboratory medicine, 2007. str. A20-A20
Barić, Ivo ; Fumić, Ksenija ; Vugrek, Oliver ; Ćuk, Mario ; Maradin, Miljenka, Glenn, Byron ; Wagner, Conrad ; Stabler, Sally ; Schulze, Andreas ; Radoš, Marko ; Sarnavka, Vladimir et al. | S-Adenosylhomocysteine (AdoHcy) hydrolase deficiency: myopathy seems to be congenital // Journal of inherited metabolic disease, 2005. str. 76-76-x
Barić, Ivo ; Glenn, B. ; Fumić, Ksenija ; Ćuk, Mario ; James, S.J. ; Pažanin, Leo ; Radoš, Marko ; Sarnavka, Vladimir ; Schulze, A. ; Šćukanec-Špoljar, Mira et al. | S-Adenosylhomocysteine (AdoHcy) hydrolase deficiency: First proven case in a human // Journal of inherited metabolic disease, 2003. str. 62-62-x
Publications - Graded papers
Diplomski rad
Mijić, Ivana | Preparation and functional analysis of human S- adenosylhomocysteine hydrolase (SAHH) isofroms SAHH-2 and SAHH-3 / Weygand-Đurešević , Ivana (mentor); Vugrek, Oliver (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2006
Regović, Maja | STVARANJE STABILNO TRANSFECIRANIH EUKARIOTSKIH STANICA HELA ZA PREKOMJERNU EKSPRESIJU ENZIMA S-Adenozilhomocistein hidrolaze / Vugrek, Oliver (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2007
Selmani, Atiđa | Prolazna ekspresija varijanti s-adenozilhomocistein-hidrolaze / Vugrek, Oliver (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2007
Doktorska disertacija
Lucija Kovačević | Nedostatak S-Adenozilhomocistein hidrolaze: Molekularni mehanizmi novog oboljenja / Oliver Vugrek (mentor); Igor Jurak (neposredni voditelj) . | Rijeka, Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova, 2017
Belužić, Robert | Nedostatak Aktivnost S-Adenozilhomocistein- Hidrolaze: Molekularna podloga novog nasljednog oboljenja / Oliver Vugrek (mentor); Oliver Vugrek (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2010
Tlak Gajger, Ivana | Uspostavljanje sustava transpozon mutageneze za bakteriju Paenibacillus larvae / Vugrek, Oliver ; Petrinec, Zdravko (mentor). | Zagreb, Veterinarski fakultet, Zagreb, 2010
Membership in professional associations / societies
2005 Croatian Society of Biochemistry and Molecular Biology
2008 Croatian Society of Human Genetics
2010- RBI commission member for intellectual property rights
2020 - member of the Commission for the implementation of the declaration on cooperation towards obtaining at least one million sequenced genomes of the EU by 2022.
2020 - National representative of the special group 'Signatories of the Declaration of cooperation 'Towards access to at least 1 million sequenced genomes in the EU by 2022'.
2021 – National representative of the Republic of Croatia in the working group 1+MG WG12 The Genome of Europe (GoE) at the European Commission.
Certificates:
Agilent technologies: Certificate of Achievement in 'Cytogenomics Software familiarization, introduction to algorithms and application to clinical cases interpretation' 2012
IAEA-WIPO (World Intellectual Property Organization) -
Certificate for advanced Innovation, Technology Transfer and Successful Technology Licensing in Research & Development Institutions, 2011
Certificate for Innovation Promotion, Technology Transfer and Successful Technology Licensing, 2010