Climate change scenarios predict a continuous increase in emissions from biomass burning (BB). This calls for a comprehensive assessment of the environmental impact of BB aerosol particles (BBA), especially their chemically reactive organic fraction (BBOA), which changes over time. To capture the extent of the future changing environment, especially in dynamic and vulnerable coastal zones, collaboration between different research fields is essential, including atmospheric chemistry, modelling, marine chemistry and biology, and toxicology. Therefore, with a holistic, multidisciplinary approach, ADRIAirBURN aims to enhance scientific knowledge on physico-chemical properties of BBA, focusing on BBOA, and how their aging in the atmosphere affects air quality, human health and marine environment in coastal zones. The project focuses on the Adriatic coast, prone to extreme fire hazards, where the impact of BB emissions remains largely unknown. To reach its goals, ADRIAirBURN proposes a comprehensive phased approach: Phase I: Investigate the variability of air quality affected by BB emissions in the Adriatic coastal area through modelling and fieldwork, considering controlled open BB events; Phase II: Understand the evolution of BBA chemical properties during atmospheric aging by combining novel aqueous-phase laboratory and chamber studies; Phase III: Assess the evolution of BBA toxicity during aging through toxicological acellular and cellular studies at the air-liquid interface and phytoplankton monocultures relevant to human health and marine phytoplankton community. By employing a state-of-the-art integral approach, ADRIAirBURN aims to reduce uncertainties in BBA representation in atmospheric models. This is crucial for understanding the extent of BBOA impacts on climate, human health and the environment.