Wastewater (WW) remediation by microalgae can offer a more ecologically friendly and economically sustainable alternative to conventional WW treatments. While bacteria produce, algae sequester CO2 from the atmosphere, and yet still have high enough growth rates and assimilation efficiencies to produce lucrative biomass that can be used in a cogenerative production of biofuels, with the added benefit of reducing eutrophication and recycling non-renewable nutrients. Utilising microalgae in industrial WW treatment is, however, difficult because of their sensitivities to environmental fluctuations and WW toxicity. With the A3PICO3G project this research group discovered that some algae can successfully grow on oil refinery WW, but additional research is necessary to make the use of microalgae in bioremediation economically sustainable. A3PHYCOTOX will utilize an iterative experimental and modelling approach to establish a scientific platform for assessment and maximization of bioremediation potential of selected microalgae species indigenous to Northern Adriatic. The research will focus on the most promising candidate species identified by A3PICO3G. An existing automated system of 4 bioreactors (PBRs) in Center for Marine Research will be used to run the growth experiments of the candidate species in the range of light, nutrient and toxicant exposure conditions relevant to WW from INA oil refinery plant. Modeling will be used for in silico identification of the optimal growth strategies, and estimate the microalgal WW phycoremediation capacity. Finally, the project will produce a proof of concept in an upscaled system to validate models, which in turn will give guidance for the economic sustainability of the phycoremediation in the cogenerative biorefinery concept.