Misija

Misija Laboratorija za molekularnu virologiju i bakteriologiju je proširivanje znanja i razumijevanja prirode tumora čovjeka povezanih sa infektivnim agensima u svrhu poboljšanja i razvijanja novih pristupa u dijagnostici, liječenju i prevenciji tih bolesti.

Djelatnost

• Bazična istraživanja molekularne patogeneze humanih papiloma virusa (HPV)
• Epidemiološka istraživanja HPV-a i drugih patogena u raznim sijelima 
• Istraživanja epigenetike HPV-povezanih bolesti
• Istraživanja uloge onkogena E6 i E7 HPV-a u razvoju HPV-povezanih bolesti
• Laboratorij je zavodska jedinica za molekularnu analizu virusnih i bakterijskih infekcija u čovjeka
• Laboratorij održava hrvatsku banku DNA i RNA stanica prekanceroza i karcinoma povezanih s HPV-om
• Laboratorij održava stanične i bakterijske kulture za uzgoj ili/i ekspresiju gena HPV-a

Publikacije u zadnjih 5 godina

1. Pešut, Ena; Šimić, Ivana; Kužilkova, Daniela; Kalina, Tomáš; Fureš, Rajko; Erceg Ivkošić, Ivana; Milutin, Nina; Sabol, Ivan. Application of Mass Cytometry in Multiparametric Characterization of Precancerous Cervical Lesions // Cytometry part b-clinical cytometry, (2024), doi: 10.1002/cyto.b.22211
2. Lulić, Lucija; Šimić, Ivana; Božinović, Ksenija; Pešut, Ena; Manojlović, Luka; Grce, Magdalena; Dediol, Emil; Sabol, Ivan; Tomaić, Vjekoslav. Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status // Cells, 13 (2024), 12; 1002, 13. doi: 10.3390/cells13121002 
3. Mandić, Katarina; Milutin Gašperov, Nina; Božinović, Ksenija; Dediol, Emil; Krasić, Jure; Sinčić, Nino; Grce, Magdalena; Sabol, Ivan; Barešić, Anja. Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers // Scientific reports, 14 (2024), 9062, 12. doi: 10.1038/s41598-024-59312-z
4. Pešut, Ena; Šimić, Ivana; Fureš, Rajko; Milutin Gašperov, Nina; Lež, Cvjetko; Feratović, Fabijan; Kukina Žvigač, Tomica; Grce, Magdalena; Erceg Ivkošić, Ivana; Sabol, Ivan. Monitoring HPV Prevalence and Risk Cofactors for Abnormal Cytology in the Post-Vaccination Period among Croatian Women // Viruses, 16 (2024), 4; 642, 10. doi: 10.3390/v16040642
5. Skelin, Josipa; Luk, Ho Yin; Butorac, Dražan; Boon, Siaw Shi; Tomaić, Vjekoslav. The effects of HPV oncoproteins on host communication networks: Therapeutic connotations // Journal of medical virology, 95 (2023), 12; e29315, 18. doi: 10.1002/jmv.29315
6. Skelin, Josipa; Đukić, Anamaria; Filić, Vedrana ; Hufbauer, Martin ; Akgul, Baki ; Thomas Miranda ; Lawrence, Banks ; Tomaić, Vjekoslav. MAML1-induced HPV E6 oncoprotein stability is required for cellular proliferation and migration of cervical tumor-derived cells // Journal of medical virology, 95 (2023), 3; 5, 19. doi: https://doi.org/10.1002/jmv.28624
7. Skelin, Josipa; Tomaić, Vjekoslav. Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis // Viruses, 15 (2023), 11; 2253, 25. doi: 10.3390/v15112253
8. Šimić, Ivana ; Božinović, Ksenija ; Milutin Gašperov, Nina ; Kordić, Mario ; Pešut, Ena ; Manojlović, Luka ; Grce, Magdalena ; Dediol, Emil ; Sabol, Ivan. Head and Neck Cancer Patients’ Survival According to HPV Status, miRNA Profiling, and Tumour Features—A Cohort Study // International journal of molecular sciences, 24 (2023), 4; 3344, 15. doi: 10.3390/ijms24043344
9. Lulić, Lucija; Jakovčević, Antonia; Kovačić, Iva; Manojlović, Luka; Dediol, Emil; Skelin, Josipa; Tomaić, Vjekoslav. HPV16 impacts NHERF2 expression in oropharyngeal cancers // Pathogens, 12 (2023), 8; 1013, 11. doi: 10.3390/pathogens12081013
10. Skelin, Josipa ; Sabol, Ivan ; Tomaić, Vjekoslav. Do or Die: HPV E5, E6 and E7 in Cell Death Evasion // Pathogens, 11 (2022), 9; 1027, 16. doi: 10.3390/pathogens11091027
11. Tomaić, Vjekoslav ; Milutin Gašperov, Nina ; Sabol, Ivan ; Grce, Magdalena. Onkogeneza povezana s HPV-om u tumorima glave i vrata // Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora, 144 (2022), 3-4; 106-111. doi: 10.26800/lv-144-3-4-7
12. Milutin Gašperov, Nina ; Sabol, Ivan ; Tomaić, Vjekoslav ; Grce, Magdalena. Epigenetički biljezi u tumorima glave i vrata: posebni osvrt na tumore orofarinksa povezane s HPV-om // Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora, 144 (2022), 3-4; 96-105. doi: 10.26800/lv-144-3-4-6
13. Lulić, Lucija ; Jakovčević, Antonia ; Manojlović, Luka ; Dediol, Emil ; Banks, Lawrence ; Tomaić, Vjekoslav. Human DLG1 and SCRIB are distinctly regulated independently of HPV-16 during the progression of oropharyngeal squamous cell carcinomas: a preliminary analysis // Cancers, 13 (2021), 17; 4461, 15. doi: 10.3390/cancers13174461
14. Pešut, Ena ; Đukić, Anamaria ; Lulić, Lucija ; Skelin, Josipa ; Šimić, Ivana ; Gašperov, Nina Milutin ; Tomaić, Vjekoslav ; Sabol, Ivan ; Grce, Magdalena. Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge // Viruses, 13 (2021), 11; 2234, 32. doi: 10.3390/v13112234
15. Glodić, Goran ; Samaržija, Miroslav ; Sabol, Ivan ; Bulat Kardum, Ljiljana ; Carević Vladić, Vesna ; Džubur, Feđa ; Jakopović, Marko ; Kuhtić, Ivana ; Marušić, Ante ; Mihelčić, Dina  et al. Risk factors for nontuberculous mycobacterial pulmonary disease (NTM-PD) in Croatia // Wiener klinische Wochenschrift, 133 (2021), 21-22; 1195-1200. doi: 10.1007/s00508-021-01923-x
16. Milutin Gašperov, Nina ; Sabol, Ivan ; Božinović, Ksenija ; Dediol, Emil ; Mravak-Stipetić, Marinka ; Licastro, Danilo ; Dal Monego, Simeone ; Grce, Magdalena. DNA methylome distinguishes head and neck cancer from potentially malignant oral lesions and healthy oral mucosa // International journal of molecular sciences, 21 (2020), 18; 6853, 23. doi: 10.3390/ijms21186853
17. Marušić, Ante ; Kuhtić, Ivana ; Mažuranić, Ivica ; Janković, Mateja ; Glodić, Goran ; Sabol, Ivan ; Stanić, Lucija. Nodular distribution pattern on chest computed tomography (CT) in patients diagnosed with nontuberculous mycobacteria (NTM) infections // Wiener klinische Wochenschrift, 133 (2020), s00508-020-01701-1, 8. doi: 10.1007/s00508-020-01701-1
18. Kirschberg, Matthias ; Heuser, Sandra ; Marcuzzi, Gian Paolo ; Hufbauer, Martin ; Seeger, Jens Michael ; Đukić, Anamaria ; Tomaić, Vjekoslav ; Majewski, Slawomir ; Wagner, Steffen ; Wittekindt, Claus  et al. ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers // Scientific reports, 10 (2020), 1; 17339, 12. doi: 10.1038/s41598-020-74311-6
19. Đukić, Anamaria ; Lulić, Lucija ; Thomas, Miranda ; Skelin, Josipa ; Saidu, Nathaniel Edward Bennett ; Grce, Magdalena ; Banks, Lawrence ; Tomaić, Vjekoslav. HPV Oncoproteins and the Ubiquitin Proteasome System: A Signature of Malignancy? // Pathogens, 9 (2020), 2; 1-27. doi: 10.3390/pathogens9020133